中药单体及复方治疗多发性硬化相关作用机制的研究进展  

Mechanisms of Chinese Medicine Monomers and Compounds in the Treatment of Multiple Sclerosis:A Review

作　　者：宋鹏鹏 关东升[2] 崔应麟[2,3] SONG Pengpeng;CUAN Dongsheng;CUI Yinglin(Henan University of Chinese Medicine,Zhengzhou 450046;Henan Province Hospital of TCM,Zhengzhou 450002;Henan Key Laboratory of Chinese Medicine for Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases,Zhengzhou 450002)

机构地区：[1]河南中医药大学,郑州450046 [2]河南省中医院,郑州450002 [3]河南省中医药防治心脑血管病重点实验室,郑州450002

出　　处：《中药药理与临床》2023年第10期93-100,共8页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家自然科学基金面上项目(编号:81673943);国家中医药管理局中医药科学技术研究专项课题(编号:GZY-KJS-2021-017)。

摘　　要：随着医学的发展,免疫性疾病的治疗开始逐渐追求个体化治疗。目前,针对多发性硬化症治疗主要以激素和免疫抑制剂为主,因其伴随明显的副作用且价格昂贵,已成为目前困扰临床医生的重要问题。中医药具有个体化和整体协调的能力,可以通过不同作用机制来发挥防治多发性硬化的作用,但仍缺少系统阐述。因此本文就近5年来中药治疗多发性硬化症的临床研究及相关作用机制进行综述,旨在为今后中药单体及复方治疗多发性硬化提供指导及思路,并为临床治疗多发性硬化提供参考。With the development of medicine,individualized therapy has become the goal in the treatment of immune diseases.At the moment,hormones and immunosuppressants are mainly used for the treatment multiple sclerosis,which,however,are expensive with obvious side effects,posing a challenge to clinicians.Traditional Chinese medicine features individualization and overall coordination,which plays a role in the prevention and treatment of multiple sclerosis through different mechanisms.Nonetheless,no relevant systematic review is available.Therefore,this paper reviews the clinical treatment of multiple sclerosis by Chinese medicine in recent years and the mechanisms,which is expected to guide the treatment of multiple sclerosis with Chinese medicine monomers and compounds and provide a reference for the clinical treatment ofthis disease.

关 键 词：中医药 多发性硬化症 作用机制 研究进展 

分 类 号：R277.7[医药卫生—中医学]