抗癫痫药左乙拉西坦临床综合评价指标体系的构建  被引量:4

Construction of clinical comprehensive evaluation index system of antiepileptic levoperacetam

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作  者:曹建英[1] 禹志霞[2] 提慧慧 宋玉环 徐德丽[1] 石仲歌 惠培业[1] CAO Jianying;YU Zhixia;TI Huihui;SONG Yuhuan;XU Deli;SHI Zhongge;HUI Peiye(Department of Pharmacy,Weifang Maternal and Child Health Care Hospital,Shandong Weifang 261061,China;Obstetrics Department,Weifang Maternal and Child Health Care Hospital,Shandong Weifang 261061,China;Science and Education Section,Weifang Maternal and Child Health Care Hospital,Shandong Weifang 261061,China)

机构地区:[1]潍坊市妇幼保健院药学部,山东潍坊261061 [2]潍坊市妇幼保健院产科,山东潍坊261061 [3]潍坊市妇幼保健院科教科,山东潍坊261061

出  处:《中国医院药学杂志》2023年第24期2814-2819,共6页Chinese Journal of Hospital Pharmacy

基  金:山东省卫生健康委员会山东省药品临床综合评价项目(编号:2022YZ028)。

摘  要:目的:构建左乙拉西坦临床综合评价指标体系,为新型抗癫痫药物左乙拉西坦临床综合评价系统化推行奠定方法学基础。方法:通过文献调研法、头脑风暴法等初步确定各维度评价指标。选取不同三甲医院23位专家,采用德尔菲法及层次分析法进行两轮函询。分析专家积极性、权威程度、意见集中程度与协调程度,判断指标体系的可靠性,基于界值法对指标进行筛选,确立最终的指标体系及权重系数。结果:在基本评价指标体系框架基础上,经过两轮专家函询后,专家权威系数为0.803,专家意见的变异系数为0.18±0.07,协调系数为0.494。最终确定左乙拉西坦综合评价指标体系,包括6个一级指标,13个二级指标,30个三级指标。结论:构建的左乙拉西坦临床综合评价指标体系具有较高的权威性与科学性,可为临床合理用药及医疗机构药品遴选提供参考。OBJECTIVE To construct a comprehensive clinical evaluation index system of levetiracetam and lay a methodological foundation for implementing systematic evaluation of the new antiepileptic agent.METHODS The study adopted literature review and brainstorming to find evaluation aspects primarily.It then selected twenty-three experts from tertiary hospitals and conducted two rounds of correspondence with the Delphi method and hierarchical analysis.It analyzed the experts’motivation,authenticity,concentration,and coordination,and determined the system reliability.The study then defined the indicators with the bounding value method and eventually established an index system with weight coefficients.RESULTS Based on the preliminary evaluation system and two rounds of expert correspondence,the calculated coefficient of authenticity is 0.803,the coefficient of variation of experts’opinions is 0.18±0.07,and that of coordination is 0.494.The comprehensive evaluation index system of levetiracetam includes 6 first-level indicators,13 second-level indicators,and 30 third-level indicators.CONCLUSION The clinical comprehensive evaluation index system of levetiracetam constructed in this study has high authenticity and scientificity.It will provide references for rational drug application in clinical and pharmaceutical practice within medical institutions.

关 键 词:左乙拉西坦 临床综合评价 德尔菲法 层次分析法 

分 类 号:R971.6[医药卫生—药品]

 

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