乙酰半胱氨酸雾化吸入结合脾多肽治疗老年重症肺部感染对血清游离COR、ACTH水平的影响  

Effects of Acetylcysteine Aerosol Inhalation Combined with Spleen Poly⁃peptide on Serum Free COR and ACTH Levels in the Treatment of Severe Pulmonary Infection in the Elderly

作　　者：吴秋静 徐晓娟 胡杰 陈芸 蒋建中[1] WU Qiujing;XU Xiaojuan;HU Jie;CHEN Yun;JIANG Jianzhong(Department of Geriatric Medicine,Yixing People's Hospital,Yixing,Jiangsu Province,214200 China)

机构地区：[1]宜兴市人民医院老年医学科,江苏宜兴214200

出　　处：《中外医疗》2023年第34期13-16,共4页China & Foreign Medical Treatment

摘　　要：目的 分析乙酰半胱氨酸联合脾多肽治疗老年重症肺部感染患者时对血清中游离皮质醇(cortisol,COR)和促肾上腺皮质激素(adrenocorticotropic hormone, ACTH)的影响。方法 选取2020年1月—2023年1月宜兴市人民医院收治的老年重症肺部感染患者80例,利用随机数表法分成对照组和观察组,每组40例。对照组接受常规治疗+乙酰半胱氨酸雾化吸入治疗,观察组在对照组基础上联合脾多肽治疗。治疗10 d后,对比两组患者治疗结果、COR水平和ACTH水平以及免疫功能。结果 治疗后,观察组有效率为97.50%,高于对照组的82.50%,差异有统计学意义(χ^(2)=5.000,P=0.025)。治疗前,两组COR、ACTH以及免疫功能指标水平比较,差异无统计学意义(P>0.05)。治疗后,观察组COR、ACTH水平低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组免疫功能指标水平高于对照组,差异有统计学意义(P<0.05)。结论 乙酰半胱氨酸和脾多肽联合应用在老年重症肺部感染患者中疗效确切,同时降低COR、ACTH水平。Objective To analyze the influence of acetylcysteine combined with splenic polypeptide in the treatment of elderly patients with severe pulmonary infections on serum free cortisol(COR)and adrenocorticotropin hormone(ACTH).Methods 80 cases of elderly patients with severe pulmonary infections admitted to Yixing People's Hospital from January 2020 to January 2023 were selected and were divided into the control group and the observation group using the random number table method,with 40 cases in each group.The control group received conventional treat-ment+acetylcysteine nebulized inhalation treatment,and the observation group was combined with splenic polypeptide treatment on the basis of the control group.After 10 d of treatment,the results of treatment,COR and ACTH levels and immune function of the two groups were compared.Results After treatment,the effective rate of the observation group was 97.50%,which was higher than 82.50%of the control group,and the difference was statistically significant(χ^(2)=5.000,P=0.025).Before treatment,there was no statistically significant difference in the levels of COR,ACTH and immune function indexes between the two groups(P>0.05).After treatment,the levels of COR and ACTH in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).After treatment,the level of immune function indexes in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The combined application of acetylcysteine and spleen polypeptide has a definite effect in elderly patients with severe pulmonary infection,and reduces the levels of COR and ACTH at the same time.

关 键 词：老年重症肺部感染 乙酰半胱氨酸 脾多肽 皮质醇 促肾上腺皮质激素 

分 类 号：R563[医药卫生—呼吸系统]