腹腔镜肝切除术与射频消融术对原发性肝癌血清标志物水平及疗效的影响  

Effect of Laparoscopic Hepatectomy and Radio Frequency Ablation on Se⁃rum Marker Level and Therapeutic Effect of Primary Liver Cancer

作　　者：谢文熙 李贝棋 王耀东[2] XIE Wenxi;LI Beiqi;WANG Yaodong(Department of Hepatobiliary Surgery,Fuding Hospital Affiliated to Fujian University of Chinese Medicine,Fuding,Fujian Province,355200 China;Department of Hepatobiliary and Pancreatic Surgery,Fujian Provincial Hospital,Fuzhou,Fujian Province,350004 China)

机构地区：[1]福建中医药大学附属福鼎医院肝胆外科,福建福鼎355200 [2]福建省立医院肝胆胰外科,福建福州350004

出　　处：《中外医疗》2023年第34期39-42,共4页China & Foreign Medical Treatment

摘　　要：目的 分析腹腔镜肝切除术和射频消融术对原发性肝癌血清标志物水平和疗效的影响。方法 随机选取2021年1月—2023年2月福鼎市医院和福建省立医院收治的70例原发性肝癌患者作为研究对象,按照随机数表法分为两组,每组35例。对照组进行腹腔镜肝切除术,观察组进行射频消融术,分析治疗后的癌胚抗原、甲胎蛋白、糖类抗原125、术后并发症、肝功能指标的变化情况。结果 观察组肝功能的谷丙转氨酶(glutamic-pyruvic transaminase, ALT)为(32.84±4.02)U/L、谷草转氨酶(glutamic-oxaloacetic transaminase, AST)为(36.58±4.49)U/L,均优于对照组,差异有统计学意义(t=11.585、7.06,P<0.05),且观察组的甲胎蛋白(alphafetoprotein, AFP)、癌胚抗原(carcinoembryonic antigen, CEA)、糖类抗原125(Carbohydrate antigen 125, CA125)水平、术后并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论 射频消融术在原发性肝癌的治疗中具有更低的并发症发生率,术后肝功能损伤小,术后肝癌相关血清标志物降低更显著等优点。Objective To analyze the effects of laparoscopic hepatectomy and radio frequency ablation on serum marker levels and efficacy of primary liver cancer.Methods A total of 70 patients with primary liver cancer admitted to Fuding City Hospital and Fujian Provincial Hospital from January 2021 to February 2023 were randomly selected as the research objects.They were divided into two groups according to the random number table method,with 35 cases in each group.The control group underwent laparoscopic hepatectomy,and the observation group underwent ra-diofrequency ablation.The changes of carcinoembryonic antigen,alpha-fetoprotein,carbohydrate antigen 125,postop-erative complications and liver function indexes after treatment were analyzed.Results The glutamic-pyruvic trans-aminase(ALT)(32.84±4.02)U/L and glutamic-oxaloacetic transaminase(AST)(36.58±4.49)U/L of liver function in the observation group were all better than those in the control group,and the differences were statistically significant(t=11.585,7.06,P<0.05).The levels of alpha-fetoprotein(AFP),carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125)and incidence of adverse reactions in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion In the treatment of primary liver cancer,radio frequency ablation has the advantages of lower incidence of adverse reactions,less postoperative liver function injury,and more significant reduction of postoperative liver cancer-related serum markers,which is worth recommending in clinic.

关 键 词：肝肿瘤切除术 射频消融术 原发性肝癌 血清标志物 

分 类 号：R4[医药卫生—临床医学]