高通量血液透析与常规血液透析治疗慢性尿毒症的临床比较  

Clinical Comparison of High Flux Hemodialysis and Conventional Hemodi⁃alysis in the Treatment of Chronic Uremia

作　　者：贾海萍 沈建松 贾婧 JIA Haiping;SHEN Jiansong;JIA Jing(Department of Nephrology,Yancheng First People's Hospital,Yancheng First Hospital Affiliated to Nanjing University Medical School,Yancheng,Jiangsu Province,224000 China)

机构地区：[1]南京大学医学院附属盐城第一医院(盐城市第一人民医院)肾内科,江苏盐城224000

出　　处：《中外医疗》2023年第34期54-57,共4页China & Foreign Medical Treatment

摘　　要：目的 探讨高通量血液透析和常规血液透析在慢性尿毒症中的治疗效果。方法 随机选取2020年6月—2021年6月盐城市第一人民医院收治的60例慢性尿毒症行血液透析治疗患者为研究对象,采用随机数表法分成对照组和观察组,每组30例。对照组采取常规血液透析治疗,观察组采取高通量血液透析治疗。对两组患者临床疗效、生化指标、营养状态评分以及并发症改善程度进行比较。结果 观察组治疗有效率为93.33%,高于对照组的73.33%,差异有统计学意义(χ^(2)=4.320,P=0.038)。治疗前,两组生化指标、营养状态评分以及并发症严重程度评分比较,差异无统计学意义(P>0.05);治疗后,观察组相关生化指标低于对照组,营养状态评分低于对照组,皮肤瘙痒评分、睡眠障碍评分以及不宁腿综合征评分低于对照组,差异有统计学意义(P<0.05)。结论 高通量血液透析方式在慢性尿毒症患者中效果更为理想,可有效清除血液毒素,同时改善患者营养状态和保护肾功能,具有积极意义。Objective To explore the therapeutic effect of high flux hemodialysis and conventional hemodialysis in chronic uremia.Methods 60 patients with chronic uremia undergoing hemodialysis treatment admitted to the Yancheng First People's Hospital from June 2020 to June 2021 were randomly selected as the study objects and di-vided into two groups of 30 cases each by using the random number table method.The control group was treated with conventional hemodialysis and the observation group was treated with high flux hemodialysis.The clinical efficacy,biochemical indexes,nutritional status scores and the degree of improvement of complications were compared between the two groups.Results The treatment efficiency of the observation group was 93.33%,which was higher than 73.33%of the control group,and the difference was statistically significant(χ^(2)=4.320,P=0.038).Before treatment,the bio-chemical indexes,nutritional status scores and complication severity scores of the two groups were compared,and the differences were not statistically significant(P>0.05);after treatment,the relevant biochemical indexes of the observa-tion group were lower than those of the control group,nutritional status scores were lower than those of the control group,and itchy skin scores,sleep disorders scores,and restless legs syndrome scores were lower than those of the control group,and the differences were statistically significant(P<0.05).Conclusion High flux hemodialysis modality is more ideal in chronic uremia patients,which can effectively remove blood toxins,and at the same time improve the nutritional status of patients and protect renal function,which has positive significance.

关 键 词：慢性尿毒症 高通量血液透析 常规血液透析 临床疗效 

分 类 号：R322[医药卫生—人体解剖和组织胚胎学]