加味当归补血汤治疗慢性心力衰竭伴贫血的Meta分析  

Meta-analysis of Modified Danggui Buxue Decoction for the Treatment of Chronic Heart Failure with Anemia

作　　者：李吉旭 张林[2] 孟宪亮[2] 李伟 陆海楠 LI Jixu;ZHANG Lin;MENG Xianliang;LI Wei;LU Hainan(Shandong University of Traditional Chinese Medicine,Jinan 250000,Shandong,China)

机构地区：[1]山东中医药大学,济南250000 [2]泰安市中医医院,山东泰安271000 [3]上海中医药大学

出　　处：《中西医结合心脑血管病杂志》2024年第2期320-325,共6页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：上海市名老中医学术经验研究工作室建设项目(No.SHGZS-2017014)。

摘　　要：目的:运用Meta分析评价加味当归补血汤治疗慢性心力衰竭伴贫血的临床疗效。方法:检索中文数据库[中国知网、维普、万方、中国生物医学文献服务系统(SinoMed)]和英文数据库(EMbase、PubMed、the Cochrane Library、Web of Science),收集加味当归补血汤治疗慢性心力衰竭伴贫血的随机对照试验(RCTs),采用RevMan 5.4.1软件进行Meta分析。结果:共纳入11项RCTs,涉及870例病人。Meta分析显示:试验组治疗后临床有效率明显高于对照组[OR=3.54,95%CI(2.34,5.35),P<0.000 01],中医证候评分明显低于对照组[MD=-3.93,95%CI(-4.57,-3.28),P<0.000 01],N末端B型利钠肽原明显低于对照组[MD=-1 104.11,95%CI(-1 669.10,-539.13),P=0.000 1],左室射血分数明显高于对照组[MD=8.02,95%CI(6.71,9.33),P<0.000 01],血红蛋白水平明显高于对照组[MD=13.52,95%CI(3.95,23.09),P=0.006]。结论:现有证据表明,加味当归补血汤可有效改善慢性心力衰竭伴贫血病人的心功能和贫血状态,提高治疗有效率。Objective:To evaluate the efficacy and safety of modified Danggui Buxue Decoction for the treatment of chronic heart failure(CHF)with anemia by Meta-analysis.Methods:The Chinese(CNKI,VIP,WanFang,SinoMed)and English(EMbase,PubMed,Cochrane Library,Web of Science)databases were searched to collect randomized controlled trials of modified Danggui Buxue Decoction for the treatment of CHF with anemia.Meta-analysis was performed using Revman 5.4.1 software.Results:A total of 11 RCTs with 870 patients were included.Meta-analysis showed that the clinical effective rate in observation group was significantly higher than that in control group(OR=3.54,95%CI 2.34-5.35,P<0.00001),the traditional Chinese medicine(TCM)score was significantly lower than that in control group(MD=-3.93,95%CI-4.57--3.28,P<0.00001),the N-terminal B-type natriuretic peptide(NT-proBNP)was significantly lower than that in control group(MD=-1104.11,95%CI-1669.10--539.13,P=0.0001),the left ventricular ejection fraction(LVEF)was significantly higher than that in control group(MD=8.02,95%CI 6.71-9.33,P<0.00001),and hemoglobin(Hb)was significantly higher than that in control group(MD=13.52,95%CI 3.95-23.09,P=0.006).Conclusion:Available evidence indicates that Modified Danggui Buxue Decoction can effectively improve cardiac function and anemia in patients with CHF and anemia,and improve clinical efficacy.

关 键 词：慢性心力衰竭 贫血 加味当归补血汤 临床疗效 META分析 

分 类 号：R259[医药卫生—中西医结合]