中医鼻病辨证序贯治疗分泌性中耳炎的疗效观察  

Observation on the efficacy of sequential treatment of secretory otitis media with traditional Chinese medicine nasal disease differentiation

作　　者：李春花 LI Chun-hua(Minqing County General Hospital,Longyan 350801,China)

机构地区：[1]闽清县总医院,350801

出　　处：《中国现代药物应用》2024年第1期32-36,共5页Chinese Journal of Modern Drug Application

摘　　要：目的探究分析中医鼻病辨证序贯治疗分泌性中耳炎的疗效。方法102例分泌性中耳炎患者,采用随机数字表法分为对照组和观察组,每组51例。对照组采用常规治疗,观察组采用中医鼻病辨证序贯治疗。比较两组患者的治疗效果,治疗前后中医证候积分及血清降钙素原(PCT)、超敏C反应蛋白(hs-CRP)、细胞因子[白细胞介素-4(IL-4)、白细胞介素-10(IL-10)、白细胞介素-12(IL-2)、干扰素-γ(IFN-γ)]、T淋巴细胞亚群(CD3^(+)、CD4^(+)以及CD8^(+))水平。结果观察组患者治疗总有效率为94.12%,高于对照组的72.55%,差异具有统计学意义(P<0.05)。治疗后,观察组患者耳胀、耳痛积分分别为(0.58±0.15)、(0.42±0.10)分,低于对照组的(0.91±0.22)、(0.64±0.20)分,差异具有统计学意义(P<0.05)。治疗后,观察组患者血清PCT、hs-CRP水平分别为(1.20±0.20)μg/L、(2.08±0.40)mg/L,低于对照组的(2.45±0.33)μg/L、(3.94±0.50)mg/L,差异具有统计学意义(P<0.05)。治疗后,观察组患者血清IL-4、IL-10、IL-2、IFN-γ水平分别为(15.89±4.12)、(11.09±4.43)、(35.45±6.35)、(43.82±6.84)ng/ml,低于对照组的(26.33±5.20)、(15.02±5.62)、(40.77±6.12)、(49.96±7.02)ng/ml,差异具有统计学意义(P<0.05)。治疗后,观察组患者CD3^(+)(73.55±16.14)%、CD4^(+)(49.88±7.09)%高于对照组的(64.75±11.69)%、(41.39±6.38)%,CD8^(+)(34.57±5.00)%低于对照组的(42.62±6.99)%,差异具有统计学意义(P<0.05)。结论对分泌性中耳炎患者采用中医鼻病辨证序贯治疗效果显著,能够明显改善患者的中医证候积分及血清PCT、hs-CRP、细胞因子、T淋巴细胞亚群水平,值得临床推广应用。Objective To investigate and analyze the efficacy of sequential treatment of secretory otitis media with traditional Chinese medicine nasal disease differentiation.Methods A total of 102 patients with secretory otitis media were divided into a control group and an observation group according to random numerical table,with 51 cases in each group.The control group was treated with routine treatment,and the observation group was treated with sequential treatment based on traditional Chinese medicine nasal disease differentiation.Both groups were compared in terms of therapeutic effect,traditional Chinese medicine syndrome score,serum procalcitonin(PCT),hypersensitive C-reactive protein(hs-CRP),cytokines[interleukin-4(IL-4),interleukin-10(IL-10),interleukin-12(IL-2),interferon-γ(IFN-γ)],T-lymphocyte subsets(CD3^(+),CD4^(+) and CD8^(+))levels before and after treatment.Results The total effective rate in the observation group was 94.12%,which was higher than that of 72.55%in the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of ear distention and otalgia in the observation group were(0.58±0.15)and(0.42±0.10)points,which were lower than those of(0.91±0.22)and(0.64±0.20)points in the control group,and the difference were statistically significant(P<0.05).After treatment,the serum PCT and hs-CRP levels in the observation group were(1.20±0.20)μg/L and(2.08±0.40)mg/L,which were lower than those of(2.45±0.33)μg/L and(3.94±0.50)mg/L in the control group,and the differences were statistically significant(P<0.05).After treatment,the serum levels of IL-4,IL-10,IL-2 and IFN-γin the observation group were(15.89±4.12),(11.09±4.43),(35.45±6.35)and(43.82±6.84)ng/ml,which were lower than those of(26.33±5.20),(15.02±5.62),(40.77±6.12)and(49.96±7.02)ng/ml in the control group,and the differences were statistically significant(P<0.05).After treatment,CD3^(+)of(73.55±16.14)%and CD4^(+)of(49.88±7.09)%in the observation group were higher than+those of(64.75±11.69)%a

关 键 词：鼻病辨证 序贯治疗 分泌性中耳炎 中医证候积分 血清降钙素原 超敏C反应蛋白 细胞因子 T淋巴细胞亚群 

分 类 号：R276.1[医药卫生—中医五官科学]