羟氯喹血药浓度影响因素的研究进展  

Research Progress on Factors Affecting the Blood Concentration of Hydroxychloroquine

作　　者：黄萱 谢菡[3] 葛卫红[3] 周玉皆[4] HUANG Xuan;XIE Han;GE Weihong;ZHOU Yujie(Department of Pharmacy,China Pharmaceutical University Nanjing Drum Tower Hospital,Nanjing 210008,China;School of Basic Medicine and Clinical Pharmacy,China Pharmaceutical University,Nanjing 210009,China;Department of Pharmacy,Nanjing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School,Nanjing 210008,China;Department of Respiratory Medicine,Nanjing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School,Nanjing 210008,China)

机构地区：[1]中国药科大学南京鼓楼医院药学部,南京210008 [2]中国药科大学基础医学与临床药学学院,南京210009 [3]南京大学医学院附属鼓楼医院药学部,南京210008 [4]南京大学医学院附属鼓楼医院呼吸与危重症医学科,南京210008

出　　处：《医药导报》2024年第2期215-220,共6页Herald of Medicine

基　　金：江苏省研究型医院学会精益化用药-石药专项科研基金项目:(JY202112);江苏省药学会-正大天晴医院药学科研基金项目:(Q202213)。

摘　　要：羟氯喹最初被用作抗疟药,由于其成本效益、安全性和有效性,现已被广泛用于治疗风湿免疫病。除了免疫调节作用外,羟氯喹还表现出抗血栓、降脂和降糖的特性。羟氯喹血药浓度和临床治疗结果和不良反应相关,并且能反映患者依从性。但由于羟氯喹药动学特征复杂,即使服用相同剂量,血药浓度在个体间表现出很大的差异。该文从生理因素、病理因素、代谢酶基因多态性、药物因素等方面探讨影响羟氯喹血药浓度的因素,以期为临床合理用药、制定个体化给药方案提供参考。Originally used as an antimalarial drug,hydroxychloroquine is now widely used in the treatment of rheumatic immune diseases due to its cost-effectiveness,safety,and efficacy.In addition to its immunomodulatory effects,hydroxychloroquine also exhibits antithrombotic,anti-hypolipidemic,and anti-hypoglycemic properties.Hydroxychloroquine blood levels are correlated with clinical outcomes and adverse reactions,and can reflect patient compliance.However,due to the complex pharmacokinetic profile of hydroxychloroquine,significant inter-individual differences in blood concentration exist even with the administration of the same dosage.This study investigates the factors affecting the blood concentration of hydroxychloroquine in terms of physiological factors,pathological factors,metabolic enzyme gene polymorphisms,and drug-related factors.The aim is to provide a reference for rational clinical use and the development of individualized dosing.

关 键 词：羟氯喹 血药浓度 影响因素 

分 类 号：R978.6[医药卫生—药品]