青年男性-人类免疫缺陷病毒感染-低骨量  

Young male⁃human immunodeficiency virus infection⁃osteopenia

作　　者：陈蓉 宋桉 陈盈宇 姜艳 李梅 夏维波 吕玮[2] 王鸥 邢小平 CHEN Rong;SONG An;CHEN Ying-yu;JIANG Yan;LI Mei;XIA Wei-bo;LYU Wei;WANG Ou;XING Xiao-ping(Department of Endocrinology,Key Laboratory of Endocrinology,National Health Commission,Peking Union Medical College Hospital,Chinese Academy of Medical Science&Peking Union Medical College,Beijing 100730,China;Department of Infectious Disease,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院,北京协和医学院,北京协和医院内分泌科,国家卫生健康委员会内分泌重点实验室,北京100730 [2]中国医学科学院,北京协和医学院,北京协和医院感染内科,北京100730

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2023年第5期476-482,共7页Chinese Journal Of Osteoporosis And Bone Mineral Research

基　　金：国家自然科学基金面上项目(82070817);中央高水平医院临床科研业务费(2022-PUMCH-B-014)。

摘　　要：骨骼疾病是人类免疫缺陷病毒(human immunodeficiency virus, HIV)感染者常见并发症之一,HIV感染及抗反转录病毒治疗(anti-retroviral therapy, ART)药物均可影响骨代谢,但因起病隐匿,容易被患者及临床医生忽略。本文报告1例青年男性在HIV感染后出现骨量减低,在ART的同时给予钙剂、维生素D及活性维生素D治疗,但ART治疗前2年,骨量进一步下降,经双膦酸盐治疗后,患者破骨细胞活性明显降低,骨量稳定。Skeletal disease is one of the common chronic complications of human immunodeficiency virus(HIV)infection.HIV infection and anti-retroviral therapy(ART)drugs cause bone loss,which has an insidious onset and can be easily overlooked by patients and clinical physicians.We reported a young male who suffered from bone loss after HIV in-fection.He was treated with calcium,vitamin D,and calcitriol when he received ART.However,during the first two years of ART,the bone mass declined further.The osteoclast activity of the patient was significantly inhibited,and the bone mass remained stable after receiving the bisphosphonate treatment.

关 键 词：人类免疫缺陷病毒 抗反转录病毒治疗 低骨量 骨质疏松 

分 类 号：R681[医药卫生—骨科学]