线粒体自噬与骨质疏松症  

Mitophagy and osteoporosis

作　　者：李俊杰 张睿智 徐又佳[1,2] LI Jun-jie;ZHANG Rui-zhi;XU You-jia(Department of Orthopaedics,the Second Affiliated Hospital of Soochow University,Suzhou 215004,Jiangsu,China;Osteoporosis Clinic Center,the Second Affiliated Hospital of Soochow University,Suzhou 215004,Jiangsu,China)

机构地区：[1]苏州大学附属第二医院骨科,苏州215004 [2]苏州大学附属第二医院骨质疏松症临床中心,苏州215004

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2023年第5期503-508,共6页Chinese Journal Of Osteoporosis And Bone Mineral Research

基　　金：国家重点研发计划(2021YFC2501702);国家自然科学基金面上项目(82072474);姑苏卫生人才计划(GSWS2020024);老年医学临床技术应用研究项目(LR2021022);江苏省体医融合促进老年骨骼健康应用工程研究中心。

摘　　要：骨质疏松症是增龄性疾病,尤其是绝经后妇女最为常见。骨稳态失衡在骨质疏松症的发生、发展中有着重要作用。作为细胞重要的防御和应激调控机制,自噬与骨稳态的维持有着密不可分的关系。线粒体自噬是自噬的一种途径,主要通过清除受损的线粒体,降低细胞内活性氧(reactive oxygen species, ROS)水平,维持细胞活性。已有研究表明,线粒体自噬与骨稳态密切相关。本文就近年线粒体自噬与骨质疏松症相关性研究进行综述,希望在该研究领域梳理一些新的思路、启发一些新的思维。Osteoporosis is a disease of aging,especially in postmenopausal women.The imbalance of bone ho-meostasis plays an important role in the occurrence and development of osteoporosis.As an important defense and stress regulation mechanism of cells,autophagy is closely related to the maintenance of bone homeostasis.Mitophagy is a pathway of autophagy,which mainly removes damaged mitochondria,reduces the level of reactive oxygen species(ROS)in cells,and maintains cell viability.Previous studies have shown that mitophagy is closely related to bone homeostasis.This article summarizes the research progress of the correlation between mitophagy and osteoporosis in recent years,hoping to sort out some new ideas and inspire some new thinking in this research field.

关 键 词：成骨细胞 破骨细胞 骨髓间充质干细胞 线粒体自噬 骨质疏松症 

分 类 号：R681[医药卫生—骨科学]