基于肿瘤相关巨噬细胞糖代谢重编程探讨胃癌“脾虚瘀毒”病机理论科学内涵  

Exploration on Scientific Connotation of Pathogenesis Theory of Gastric Cancer“Spleen Deficiency and Stasis Toxin”Based on the Reprogramming of Glucose Metabolism in Tumor-associated Macrophages

作　　者：杨培培 黄雯洁 李秋蓉 王柳翔 牛晓涛 舒鹏[1,2] YANG Peipei;HUANG Wenjie;LI Qiurong;WANG Liuxiang;NIU Xiaotao;SHU Peng(Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China;Nanjing University of Chinese Medicine,Nanjing 210029,China)

机构地区：[1]南京中医药大学附属医院,江苏南京210029 [2]南京中医药大学,江苏南京210029

出　　处：《中国中医药信息杂志》2024年第2期6-10,共5页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金(82374539);国家中医药管理局《中医药循证能力建设项目》(2019XZZX-ZL003);国家中医药管理局重大疑难疾病中西医临床协作试点项目(2018年);国家中医临床研究基地开放课题(JD2019SZ11);江苏省中医药科技发展计划重点项目(ZD202214);江苏省研究生实践创新计划(SJCX23_0888)。

摘　　要：胃癌“脾虚瘀毒”病机理论认为,脾为气血生化之源,脾虚为致病内在依据,亦是胃癌病机根本,贯穿始终,瘀毒于脾虚基础上渐生,为重要病理因素。在胃癌病变过程中,肿瘤细胞与肿瘤微环境中多种代谢物质,以糖代谢重编程为主发生代谢改变,重构肿瘤相关巨噬细胞表型及功能,该过程与“脾虚瘀毒”病机理论相契合。本文聚焦肿瘤微环境糖代谢重编程驱动肿瘤相关巨噬细胞表型重塑,探讨胃癌“脾虚瘀毒”病机理论科学内涵,为中医药治疗胃癌的理论及临床研究提供参考。The pathogenesis theory of“spleen deficiency and stasis toxin”in gastric cancer holds that spleen is the source of generation and transformation of qi and blood,that spleen deficiency is the internal basis of disease and throughout the disease.Stasis toxin is based on spleen deficiency,which is the fundamental pathogenesis of gastric cancer.In the pathological process of gastric cancer,a variety of metabolic substances in tumor cells and tumor microenvironment,mainly glucose metabolic reprogramming,undergo metabolic changes to reconstruct the phenotype and function of tumor-related macrophages,which is consistent with the pathogenesis theory of“spleen deficiency and stasis toxin”.Therefore,this article focused on the reprogramming of glucose metabolism in tumor microenvironment to drive the phenotypic remodeling of tumor-related macrophages,explored the scientific connotation of the pathogenesis theory of“spleen deficiency and stasis toxin”of gastric cancer,and provided references for the theoretical and clinical research on the treatment of gastric cancer by TCM.

关 键 词：脾虚瘀毒 肿瘤微环境 肿瘤相关巨噬细胞 糖代谢重编程 胃癌 中医学 

分 类 号：R273.52[医药卫生—中西医结合]