基于自主研发ACU&MOX-DATA平台探索腧穴功效特点研究  

Exploration on Characteristics of Acupoint Efficacy Based on the Self-developed ACU&MOX-DATA Platform

作　　者：李思慧 刘书庆 唐强 张瑞斌 陈伟[3] 洪浩 朱冰梅 蓝勋 王勇[6] 余曙光[1] 吴巧凤[1,2] LI Sihui;LIU Shuqing;TANG Qiang;ZHANG Ruibin;CHEN Wei;HONG Hao;ZHU Bingmei;LAN Xun;WANG Yong;YU Shuguang;WU Qiaofeng(Acupuncture and Moxibustion College,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China;Institute of Acupuncture&Homeostasis,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China;Institute of Innovation Research,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China;West China Hospital of Sichuan University,Chengdu 610044,China;Tsinghua University Medical School,Beijing 100084,China;Academy of Mathematics and Systems Science,Chinese Academy of Sciences,Beijing 100190,China)

机构地区：[1]成都中医药大学针灸推拿学院,四川成都610075 [2]成都中医药大学针灸与内稳态研究所,四川成都610075 [3]成都中医药大学创新研究院,四川成都610075 [4]四川大学华西医院,四川成都610044 [5]清华大学医学院,北京100084 [6]中国科学院数学与系统科学研究院,北京100190

出　　处：《中国中医药信息杂志》2024年第2期64-69,共6页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家重点研发计划(2022YFC3500703、2019YFC1709001);国家自然科学基金(82174512);国家中医药管理局中医药创新团队及人才支持计划(ZYYCXTD-D-202003);四川省重大科技专项(2022ZDZX0033);成都中医药大学杏林学者青年创新团队项目(QNTD2022003)。

摘　　要：目的基于ACU&MOX-DATA平台,初步明确不同腧穴、不同靶器官及不同刺灸法对腧穴功效的影响,并可视化展示相关结果是否存在腧穴功效“特性”“共性”的特点。方法以原创组学数据和公共组学数据整合后获得的多源异构数据作为数据源,经标准化处理后,利用ACU&MOX-DATA平台中Batch Search、Stimulation Mode等模块对不同腧穴、不同靶器官、不同刺灸法的数据进行差异基因分析、疾病病理网络分析和富集分析。结果在同一疾病状态、同一干预措施下,不同腧穴间存在效应差异;在同一疾病状态、同一腧穴及干预措施下,不同靶器官产生的应答不完全一致;在同一疾病状态、同一腧穴下,不同干预措施间存在效应差异。结论基于ACU&MOX-DATA平台,初步明确腧穴、靶器官、刺灸法是影响腧穴功效的关键因素,上述结果间存在腧穴功效的特异性或共性调节特点。将ACU&MOX-DATA平台应用于针灸学领域关键科学问题的分析和可视化解读,可为深化腧穴认知、指导临床选穴、提高针灸临床疗效等提供参考。Objective To explore the effects of different acupoints,different target organs,and different interventions on acupoint efficacy based on ACU&MOX-DATA platform;To illustrate and visualize whether the above factors have the characteristics of“specific effect”or“common effect”of acupoint efficacy.Methods The multi-source heterogeneous data were integrated from the original omics data and public omics data.After standardization,differential gene analysis,disease pathology network analysis,and enrichment analysis were performed using Batch Search and Stimulation Mode modules in ACU&MOX-DATA platform under the conditions of different acupoints,different target organs,and different interventions.Results Under the same disease state and the same intervention,there were differences in effects among different acupoints;under the same disease state,the same acupoint and intervention,the responses produced by different target organs were not completely consistent;under the same disease state and acupoint,there were differences in effects among different intervention measures.Conclusion Based on the analysis of ACU&MOX-DATA platform,it is preliminary clear that acupoints,target organs,and interventions are the key factors affecting acupoint efficacy.Meanwhile,the above results have indicated that there are specific or common regulatory characteristics of acupoint efficacy.Applying ACU&MOX-DATA platform to analyze and visualize the critical scientific problems in the field of acupuncture and moxibustion can provide references for deepening acupoint cognition,guiding clinical acupoint selection,and improving clinical efficacy.

关 键 词：腧穴功效 针灸干预方式 靶器官响应 多组学数据 异源数据分析 

分 类 号：R2-03[医药卫生—中医学]