剪切波弹性成像评估重型β-地中海贫血患儿肝脏超铁负荷:与肝脏MR T2^(*)值及血清铁蛋白的相关性  

Shear wave elastography for evaluating hepatic iron overload in children withβ-thalassemia major:Correlations with MR T2^(*)value and serum ferritin

作　　者：陈幕荣 刘婷婷 陈伟玲[2] 孙亚芳 刘四喜[3] 夏焙[1,2] CHEN Murong;LIU Tingting;CHEN Weiling;SUN Yafang;LIU Sixi;XIA Bei(Shenzhen Pediatrics Institute of Shantou University Medical College,Shenzhen 518000,China;Department of Ultrasound,Shenzhen Children's Hospital,Shenzhen 518038,China;Department of Hematology Oncology,Shenzhen Children's Hospital,Shenzhen 518038,China)

机构地区：[1]汕头大学医学院深圳儿科临床学院,广东深圳518000 [2]深圳市儿童医院超声影像科,广东深圳518038 [3]深圳市儿童医院血液肿瘤科,广东深圳518038

出　　处：《中国医学影像技术》2024年第1期73-76,共4页Chinese Journal of Medical Imaging Technology

基　　金：广东省高水平医院建设经费深圳市儿童医院高水平医院建设院内医学平台资助[深儿医科教(2023)7号];广东省高水平临床重点专科(深圳市配套建设经费)资助(SZGSP012)。

摘　　要：目的观察剪切波弹性成像(SWE)评估重型β-地中海贫血(β-TM)患儿超铁负荷的价值,及其参数与肝脏MR T2^(*)值及血清铁蛋白的相关性。方法回顾性分析96例β-TM患儿及100名健康儿童(对照组),根据是否接受造血干细胞移植(HSCT)将患儿分为HSCT组(n=41)或无HSCT组(n=55),比较3组SWE参数;采用Spearman相关分析观察肝脏剪切波速度(LSWV)与肝脏MR T2^(*)值及血清铁蛋白、杨氏模量与肝脏MR T2^(*)值及血清铁蛋白的相关性。结果HSCT组、无HSCT组LSWV及杨氏模量均高于对照组(P均<0.001);HSCT组与无HSCT组LSWV及杨氏模量差异均无统计学意义(P均>0.05)。β-TM患儿SWE参数与MR T2^(*)值均呈中度负相关(r=-0.501,P<0.05;r=-0.514,P<0.05)、与血清铁蛋白均呈低度正相关(r=0.488,P<0.05;r=0.470,P<0.05)。结论SWE可用于评估β-TM患儿肝脏超铁负荷;SWE参数与MR T2^(*)值呈负相关、与血清铁蛋白呈正相关。Objective To observe the value of shear wave elastography(SWE)for evaluating hepatic iron overload in children withβ-thalassemia major(β-TM),as well as the correlations of relative parameters with MR T2^(*)value and serum ferritin.Methods Totally 96 children withβ-TM and 100 healthy children(control group)were retrospectively enrolled.Children withβ-TM were divided into hematopoietic stem cell transplantation(HSCT)group(n=41)or non-HSCT group(n=55)according to underwent HSCT or not.SWE parameters were compared among groups.Spearman correlation was performed to observe the correlations of liver shear wave velocity with MR T2^(*)value and serum ferritin,as well as Young's modulus with MR T2^(*)value and serum ferritin in children withβ-TM.Results Liver shear wave velocity(LSWV)and Young's modulus in HSCT group and non-HSCT group were all higher than those in control group(all P<0.001).No significant difference of LSWV nor Young's modulus was found between HSCT group and non-HSCT group(both P>0.05).SWE parameters of children withβ-TM were moderately and negatively correlated with MR T2^(*)value(r=-0.501,P<0.05;r=-0.514,P<0.05),while weakly and positively correlated with serum ferritin(r=0.488,P<0.05;r=0.470,P<0.05).Conclusion SWE was helpful for evaluating hepatic iron overload in children withβ-TM,with parameters being negatively correlated with MR T2^(*)value and positively correlated with serum ferritin.

关 键 词：Β地中海贫血 铁过载 儿童 超声检查 

分 类 号：R725.5[医药卫生—儿科] R445.1[医药卫生—临床医学]