病毒感染与宿主抗感染免疫之间“博弈”——凋亡、坏死和焦亡分子机制  

Molecular Mechanism of the"Battle"between Virus Infection and Host Antiviral Immunity-Apoptosis,Necroptosis and Pyroptosis

作　　者：陈松彪 刘飞飞[1,2] 尚珂 余祖华 何雷[1,2] 魏颖 陈建[1,2] 张春杰 程相朝[1,2] 丁轲 CHEN Songbiao;LIU Feifei;SHANG Ke;YU Zuhua;HE Lei;WEI Ying;CHEN Jian;ZHANG Chunjie;CHENG Xiangchao;DING Ke(Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention and Control,Henan University of Science and Technology,Luoyang 471003,China;Laboratory of Functional Microbiology and Animal Health,Henan University of Science and Technology,Luoyang 471003,China;Key Laboratory for Animal Pathogens and Biosafety,Ministry of Education,Zhengzhou 450000,China)

机构地区：[1]洛阳市活载体生物材料与动物疫病防控重点实验室,洛阳471003 [2]河南科技大学功能微生物与畜禽健康实验室,洛阳471003 [3]动物病原与生物安全教育部重点实验室,郑州450000

出　　处：《畜牧兽医学报》2024年第1期59-70,共12页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：河南省科技研发计划联合基金资助项目(232103810029);河南省自然科学基金资助项目(232300421263);河南科技大学博士启动基金资助项目(13480104)。

摘　　要：细胞死亡是宿主抗病毒感染免疫的重要组成部分,病毒感染可引起不同形式宿主细胞死亡,包括溶解性和非溶解性两种细胞死亡类型。这两种细胞死亡类型不仅能够消除病毒感染细胞,而且还能够利用炎症因子释放进一步促进宿主先天和适应性免疫进程。反之,病毒也发展出不同规避机制来抑制宿主细胞死亡进而促进自身感染。本文就病毒感染与宿主抗病毒感染免疫之间的“博弈”——凋亡、坏死和焦亡调控机制研究进展进行综述,旨在为深入理解病毒的分子致病机制以及开发新的抗病毒策略提供参考资料。Cell death is an important component of host antiviral immunity response,viral infection can cause different forms of host cell death,including the lytic and non-lytic cell death mode.These types of cell death not only eliminate virus-infected cells,but also further promote the host’s innate and adaptive immune processes through release of inflammatory factors.On the contrary,viruses have developed different circumvention mechanisms to inhibit cell death and promote itself infection.This review summarized the research progress in the regulation mechanism of virus-host infection and anti-infection immunity struggle-apoptosis,necroptosis and pyroptosis,aiming to provide references for further understanding the viral molecules pathogenesis and developing a new antiviral strategy.

关 键 词：病毒 宿主 博弈 凋亡 坏死 焦亡 

分 类 号：S855.3[农业科学—临床兽医学]