小剂量阿奇霉素治疗慢性中度持续期哮喘患儿的临床效果  

Clinical effect of low-dose Azithromycin in the treatment of children with chronic moderate persistent asthma

作　　者：农常亮 黄楚洪 韦未红 廖景贵 孙瑀泽 潘美琴 NONG Changliang;HUANG Chuhong;WEI Weihong;LIAO Jinggui;SUN Yuze;PAN Meiqin(Department of Pediatrics,the Second Nanning People’s Hospital,Guangxi Zhuang Autonomous Region,Nanning 530031,China;Department of Ultrasound Medicine,the Second Nanning People’s Hospital,Guangxi Zhuang Autonomous Region,Nanning 530031,China)

机构地区：[1]南宁市第二人民医院儿科,广西南宁530031 [2]南宁市第二人民医院超声医学科,广西南宁530031

出　　处：《妇儿健康导刊》2024年第1期94-97,共4页JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE

基　　金：广西壮族自治区卫生健康委员会自筹经费科研课题(Z20210080)。

摘　　要：目的探讨小剂量阿奇霉素治疗慢性中度持续期哮喘患儿的临床效果。方法选取2022年1月至2023年1月于南宁市第二人民医院治疗的50例慢性中度持续期哮喘患儿为研究对象,按照随机数字表法分为对照组与观察组,每组各25例。对照组采用布地奈德福莫特罗粉吸入剂治疗,观察组在对照组基础上采用小剂量阿奇霉素治疗。比较两组的肺功能指标、炎症因子水平、治疗总有效率、不良反应总发生率。结果治疗后,观察组第1秒用力呼气容积(FEV1)/用力肺活量、FEV1占预计值百分比高于对照组,白细胞介素(IL)-18、IL-6、超敏C反应蛋白水平低于对照组(P<0.05);观察组治疗总有效率高于对照组(P<0.05),不良反应总发生率低于对照组(P<0.05)。结论小剂量阿奇霉素治疗慢性中度持续期哮喘患儿的临床效果显著,能够改善肺功能,减轻炎症反应,降低不良反应发生率,值得推广。Objective To investigate the clinical effect of low-dose Azithromycin in the treatment of children with chronic moderate persistent asthma.Methods A total of 50 children with chronic moderate persistent asthma in the Second Nanning People’s Hospital from January 2022 to January 2023 were selected and divided into control group and observation group by the random number table method,with 25 cases in each group.The control group was treated with Budesonide Formoterol Powder Inhalation,while the observation group was treated with low-dose Azithromycin on the basis of control group.The pulmonary function index,inflammatory factor level,total effective rate and total incidence of adverse reactions were compared between the two groups.Results The the forced expiratory volume in one second(FEV1)/forced vital capacity and FEV1%/predicted value ratio in the observation group were higher than those in the control group(P<0.05),the levels of interleukin(IL)-18,IL-6 and hypersensitive C-reactive protein in the observation group were lower than those in the control group(P<0.05).The total effective rate in the observation group was higher than that in the control group,and the total incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion Low-dose Azithromycin treating children with chronic moderate persistent asthma has significant clinical effect,which can improve lung function,reduce inflammation reactions,decrease the incidence of adverse reactions,and is worth promoting.

关 键 词：慢性中度持续期哮喘 儿童 阿奇霉素 肺功能 炎症因子 

分 类 号：R725.6[医药卫生—儿科]