宁波市中心城区≥15岁人类免疫缺陷病毒感染者/艾滋病患者乙型肝炎病毒血清流行率  

Seroprevalence of hepatitis B virus among ≥15-year-olds living with human immunodeficiency virus infection/acquired immune deficiency syndrome (HIV/AIDS) in a central urban area of Ningbo city

作　　者：李萍萍[1] 王慧 廖于峰[3] 吴锋[1] Li Pingping;Wang Hui;Liao Yufeng;Wu Feng(Jiangbei District Center for Disease Control and Prevention,Ningbo 315020,Zhejiang,China;Haishu District Center for Disease Control and Prevention,Ningbo 315200,Zhejiang,China;The Second Hospital of Ningbo,Ningbo 315000,Zhejiang,China)

机构地区：[1]宁波市江北区疾病预防控制中心,浙江宁波315200 [2]宁波市海曙区疾病预防控制中心,浙江宁波315200 [3]宁波市第二医院,浙江宁波315000

出　　处：《中国疫苗和免疫》2023年第6期613-619,共7页Chinese Journal of Vaccines and Immunization

基　　金：江北区科技局社发类项目(2022C01)。

摘　　要：目的 了解宁波市中心城区人类免疫缺陷病毒(Human immunodeficiency virus,HIV)感染者/艾滋病(Acquired immune deficiency syndrome,AIDS)患者乙型肝炎(乙肝)病毒(Hepatitis B virus,HBV)血清流行率。方法 选择2022年12月31日前宁波市江北区和海曙区所有治疗随访管理的≥15岁HIV感染者/AIDS患者开展问卷调查和血清标本采集,检测HBV表面抗原(HBV surface antigen,HBsAg)、表面抗体(HBV surface antibody,HBsAb)、核心抗体(HBV core antibody,HBcAb)、e抗原(HBV e antigen,HBeAg)和e抗体(HBV e antibody,HBeAb),分析HBV标志物阳性率、感染率和组合模式。结果 共纳入调查对象1 163名,HBsAg、HBsAb和HBcAb阳性率分别为8.86%、57.61%和51.33%,HBV感染率为62.34%;在HBsAg阳性者中HBeAg和HBeAb阳性率分别为22.33%和67.96%。共检测出12种HBV标志物组合模式,其中HBsAb单独阳性、全部标志物阴性、HBsAg+HBeAg+HBcAb阳性、HBsAg+HBeAb+HBcAb阳性和HBsAg+HBcAb阳性者分别占所有调查对象的25.97%、23.36%、1.98%、5.67%和0.69%。结论 调查地区≥15岁HIV感染者/AIDS患者HBV感染率和传染性高,且存在大量HBV易感者;需定期开展该人群HBV标志物检测和尽早抗病毒治疗,并实施高危人群乙肝免疫策略。Objective To determine the seroprevalence of hepatitis B virus(HBV) among individuals ≥15 years old who are living with human immunodeficiency virus infection/acquired immune deficiency syndrome(HIV/AIDS).Methods We selected all individuals ≥15 years of age living with HIV/AIDS who were treated and followed up in Jiangbei and Haishu districts of Ningbo city through December 31,2022 for a questionnaire-based survey.We obtained serum samples and tested sera for HBV surface antigen(HBsAg),surface antibody(HBsAb),core antibody(HBcAb),e antigen(HBeAg),and e antibody(HBeAb) to determine seropositivity,susceptibility,previous HBV infection,and the distribution of patterns of HBV markers.Results A total of 1 163 subjects were included in the survey.Positivity rates of HBsAg,HBsAb,and HBcAb were 8.86%,57.61%,and 51.33%,respectively,with an HBV infection rate of 62.34%.Subjects who were positive for HBeAg and HBeAb accounted for 22.33% and 67.96% of HBsAg-positive subjects.Twelve patterns of HBV markers were identified;subjects who were positive for only HBsAb,were negative to all markers,and were positive for HBsAg+HBeAg+HBcAb,HBsAg+HBeAb+HBcAb,or HBsAg+HBcAb accounted for 25.97%,23.36%,1.98%,5.67%,and 0.69% of all subjects.Conclusions The HBV infection rate was high among people ≥15 years of age living with HIV/AIDS in the survey area,with a significant number of individuals susceptible to HBV.We should regularly conduct HBV marker detection to enable early antiviral therapy as indicated and implement hepatitis B immunization strategies for this high-risk population.

关 键 词：乙型肝炎 乙型肝炎病毒 血清标志物 血清流行率 人类免疫缺陷病毒感染 艾滋病 

分 类 号：R186[医药卫生—流行病学]