2020-2022年湖南省三个区县0-19岁健康人群风疹抗体水平调查  

Rubella antibody levels in a healthy population 0-19 years of age in three counties of Hunan province,2020-2022

作　　者：赖智维 张淑君[1] 方明礼[1] 李芳彩[1] 聂勇 李恒 盛寒玉 Lai Zhiwei;Zhang Shujun;Fang Mingli;Li Fangcai;Nie Yong;Li Heng;Sheng Hanyu(Hunan Provincial Center for Disease Control and Prevention,Changsha 410153,Hunan,China;Dingcheng Center for Disease Control and Prevention,Changde 415100,Hunan,China;Rucheng Center for Disease Control and Prevention,Chenzhou 424100,Hunan,China;Shuangpai Center for Disease Control and Prevention,Yongzhou 425200,Hunan,China)

机构地区：[1]湖南省疾病预防控制中心,湖南长沙410153 [2]鼎城区疾病预防控制中心,湖南常德415100 [3]汝城县疾病预防控制中心,湖南郴州424100 [4]双牌县疾病预防控制中心,湖南永州425200

出　　处：《中国疫苗和免疫》2023年第6期655-660,共6页Chinese Journal of Vaccines and Immunization

基　　金：国家科技重大专项(2018ZX10713002)。

摘　　要：目的 了解湖南省0-19岁健康人群风疹抗体水平。方法 于2020-2022年采用多阶段抽样方法选取湖南省3个区县0-19岁健康人群,检测血清标本风疹IgG抗体,分析抗体阳性率和几何平均浓度(Geometric mean concentration,GMC)。结果 调查对象风疹IgG抗体总阳性率、GMC分别为81.87%(2 203/2 691)、46.56IU/mL;0-7月龄、8-23月龄、2-4岁、5-14岁、15-19岁人群抗体阳性率分别为65.22%、82.99%、89.69%、80.78%、77.00%。多因素回归模型分析显示,在0-7月龄人群中,双牌县、鼎城区人群风疹IgG抗体阳性率高于汝城县[OR(95%CI):1.44(1.11-1.88)、1.52(1.18-1.96)];在8月龄-19岁人群中,1剂次、≥2剂次含风疹成分疫苗(Rubella-containing vaccine,RCV)免疫史人群风疹IgG抗体阳性率高于无免疫史人群[OR(95%CI):2.48(1.26-4.90)、2.64(1.27-5.49)];有RCV免疫史人群抗体浓度随RCV免疫后时间的增加而下降(β=-0.06,95%CI:-0.10~-0.02)。结论 调查地区0-19岁人群风疹抗体水平总体较高,且主要受RCV免疫史的影响。需继续保持适龄儿童高水平RCV接种率。Objective To determine rubella antibody levels among a healthy population aged 0-19 years in Hunan province.Methods We used a multistage sampling method to select healthy individuals aged 0-19 years from 3 counties of Hunan.We tested serum samples for rubella IgG antibody to determine positivity rates and geometric mean concentrations(GMC).Results The overall positivity rate and GMC of rubella IgG antibody were 81.87%(2 203/2 691) and 46.56IU/mL,respectively.Positivity rates for 0-7-month-olds,8-23-month-olds,2-4-year-olds,5-14-year-olds,and 15-19-year-olds were 65.22%,82.99%,89.69%,80.78%,and 77.00%.Multivariate regression analyses showed that positivity rates among 0-7-month-old subjects were higher in Shuangpai and Dingcheng counties than in Rucheng county [OR(95%CI):1.44(1.11-1.88) and 1.52(1.18-1.96)];positivity rates among subjects aged 8 months to 19 years were higher among subjects who had received 1 dose or ≥2 doses of rubella containing vaccine(RCV) than among subjects who had not received RCV [OR(95%CI):2.48(1.26-4.90) and 2.64(1.27-5.49)];and IgG antibody concentrations declined over time since RCV vaccination(β=-0.06,95%CI:-0.10~-0.02).Conclusions The rubella antibody level was generally high among the healthy population aged 0-19 years in the surveyed areas and were mainly influenced by RCV vaccination.We should maintain high RCV coverage in age-eligible children.

关 键 词：风疹 含风疹成分疫苗 IGG抗体 影响因素 健康人群 

分 类 号：R186[医药卫生—流行病学] R511.2[医药卫生—公共卫生与预防医学]