宁夏回族自治区北部地区2-70岁人群1剂次流行性乙型脑炎减毒活疫苗免疫原性观察  

Immunogenicity of one dose of Japanese encephalitis attenuated live vaccine among 2-70-year-olds in north Ningxia Hui Autonomous Region

作　　者：张颖[1] 周路平[1] 周洋 刘玮 付士红[2] 王环宇[2] 李海军[1] 周莉薇[1] Zhang Ying;Zhou Luping;Zhou Yang;Liu Wei;Fu Shihong;Wang Huanyu;Li Haijun;Zhou Liwei(Ningxia Hui Autonomous Region Center for Disease Control and Prevention,Yinchuan 750004,Ningxia,China;National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China)

机构地区：[1]宁夏回族自治区疾病预防控制中心,宁夏银川750004 [2]中国疾病预防控制中心病毒病预防控制所,北京102206

出　　处：《中国疫苗和免疫》2023年第6期661-664,共4页Chinese Journal of Vaccines and Immunization

基　　金：宁夏卫生健康系统科研课题(2019-NW-055)。

摘　　要：目的 分析2-70岁人群接种流行性乙型脑炎减毒活疫苗(Japanese encephalitis attenuated live vaccine,JEV-L)的免疫原性及其影响因素。方法 采用非随机、非对照的观察研究在宁夏北部地区招募2-70岁且血清乙脑病毒中和抗体阴性的健康人群,接种1剂次JEV-L;采用蚀斑减少中和试验检测免疫后1个月血清乙脑病毒中和抗体,分析抗体阳转率及其影响因素。结果 研究对象1剂次JEV-L免疫后乙脑病毒中和抗体阳转率为68.28%(99/145),其中2-10岁、11-20岁、21-40岁、41-70岁年龄组分别为90.32%、78.26%、66.67%、54.10%,乙脑流行区、低流行区分别为73.45%、50.00%,既往有、无乙脑疫苗免疫史者分别为83.33%、62.14%。多因素分析显示地区流行强度和既往乙脑疫苗免疫史是抗体阳转率的影响因素。结论 1剂次JEV-L在乙脑流行区或既往有乙脑疫苗免疫史的2-70岁人群中免疫原性良好。Objective To explore the immunogenicity of one dose of Japanese encephalitis attenuated live vaccine(JEV-L) among a population 2-70 years of age and factors influencing immunogenicity.Methods We recruited 2-70-year-old healthy individuals who were negative to neutralizing antibodies against Japanese encephalitis virus(JEV) into a non-randomized,uncontrolled observational study.Each subject received one dose of JEV-L.We tested sera for JEV neutralizing antibody using plaque reduction neutralization assays to determine the seroconversion rate and factors influencing seroconversion.Results The seroconversion rate was 68.28%(99/145) after one dose of JEV-L.Seroconversion rates among 2-10-,11-20-,21-40-,and 41-70-year-olds were 90.32%,78.26%,66.67%,and 54.10%,respectively.Seroconversion was 73.45% among subjects who lived in epidemic regions and 50.00% among subjects who lived in low-epidemic regions.Seroconversion was 83.33% among subjects who previously had received JE vaccine and 62.14% among subjects who had not previously received JE vaccine.Multivariate analysis showed that regional epidemic status and JE vaccination history were factors influencing seroconversion.Conclusions Immunogenicity of one dose of JEV-L given to neutralizing-antibody-negative 2-70-year-olds was better among those who lived in an epidemic region or who had a history of prior JE vaccination.

关 键 词：流行性乙型脑炎 乙型脑炎减毒活疫苗 免疫原性 

分 类 号：R186[医药卫生—流行病学] R512.62[医药卫生—公共卫生与预防医学]