血清同型半胱氨酸补体C3 C4与老年突发性耳聋预后的相关分析  

Correlation analysis of serum Hcy,complement C3,C4 and prognosis in elderly patients with sudden deafness

作　　者：李梅 Li Mei(Department of Laboratory,Traditional Chinese Medicine Hospital in Hekou District,Dongying,Shandong 257200,China)

机构地区：[1]东营市河口区中医院检验科,山东东营257200

出　　处：《实用医技杂志》2023年第10期714-717,共4页Journal of Practical Medical Techniques

摘　　要：目的探究血清同型半胱氨酸(Hcy)、补体C3、C4与老年突发性耳聋患者预后的相关关系。方法选择2020年5月至2021年12月110例在山东省东营市河口区中医院住院的突发性耳聋患者为突聋组,另选取同期110名健康体检者为对照组,比较2组患者的免疫指标(补体C3、C4)水平、血清Hcy,并比较突发性耳聋患者的治疗效果与血清Hcy、补体C3、C4水平相关关系,采用多因素Logistic回归分析探究影响疗效的因素。结果突聋组补体C3、C4均低于对照组(P<0.05),突发性耳聋组治疗前血清Hcy水平均高于对照组(P<0.05)。多因素Logistic回归显示,平均听阈71~90 dBHL、全聋型、补体C3下降,血清Hcy水平升高为老年突发性耳聋的独立危险因素(P<0.05);Spearman相关分析显示,突聋患者血清Hcy水平与平均听阈呈正相关(P<0.05),补体C3、C4均与平均听阈呈负相关(P<0.05)。结论高血清Hcy、低补体C3、C4是突发性耳聋的危险因素,将Hcy、补体C3、C4水平控制在适当水平能够有效预防患者发生突发性耳聋。Objective To explore the correlation between serum Hcy,complement C3,C4 and the prognosis in elderly patients with sudden deafness.Methods One hundred and ten hospitalized patients with sudden deafness from May 2020 to December 2021 were selected as the sudden deafness group,and 110 those who have a health check-up individuals in the same period were selected as the control group.The immune indicators(complement C3,C4)levels and serum homocysteine(Hcy)of the two groups of patients were compared,and the serum Hcy,complement C3 levels,C4 and their correlation with the treatment effect of sudden deafness patients were compared.Multivariate logistic regression analysis was used to explore the factors affecting the prognosis of the therapeutic effect.Results The complement C3 and C4 of the sudden deafness group were lower than those in the control group(P<0.05),and the serum Hcy levels in the sudden deafness group before treatment were higher than those in the control group(P<0.05).Multivariate logistic regression showed that the average hearing threshold of 71~90 dBHL,total deafness type,decreased complement C3,and elevated serum Hcy levels were independent risk factors for elderly patients with sudden deafness(P<0.05).Spearman correlation analysis showed that serum HCY levels in patients with sudden deafness were positively correlated with the mean hearing threshold(P<0.05),and complement C3 and C4 were both negatively correlated with the mean hearing threshold(P<0.05).Conclusion High serum Hcy,low complement C3,and C4 are risk factors for the development of sudden deafness,and controlling the levels of Hcy,complement C3,and C4 at an appropriate levels can effectively prevent the development of sudden deafness in patients,and their predictive ability is more sensitive.

关 键 词：半胱氨酸 补体C3 补体C4 突发性耳聋 老年 预后 

分 类 号：R764.437[医药卫生—耳鼻咽喉科]