循环及眼生物液标志物在早期糖尿病视网膜病变筛查和风险分层管理中的研究进展  

Research progress of circulating and ocular biomarkers in screening and risk stratification and management of patients with early diabetic retinopathy

作　　者：黄婵妍 张妍春 郑嘉敏 王鑫晨 Huang Chanyan;Zhang Yanchun;Zheng Jiamin;Wang Xinchen(Department of Chinese Medicine,First Clinical Medical College,Shaanxi University of Chinese Medicine,Xianyang 712000,China;Shaanxi Eye Hospital,Xi′an People′s Hospital(Xi′an Fourth Hospital),Diabetes Retinopathy Center of Shaanxi Provincial Eye Hospital,Affiliated People′s Hospital of Northwest University,Xi′an Ocular Fundus Disease Research Institute,Xi′an 710004,China)

机构地区：[1]陕西中医药大学第一临床医学院中医系,咸阳712000 [2]西安市人民医院(西安市第四医院)眼科、陕西省眼科医院糖尿病视网膜病变中心、西北大学附属人民医院、西安市眼底病研究所,710004

出　　处：《中华眼科医学杂志（电子版）》2023年第5期306-310,共5页Chinese Journal of Ophthalmologic Medicine(Electronic Edition)

基　　金：陕西省重点研发计划项目(2021SF-162);西安市科技计划重大研究项目(201805104YX12SF38(3));白求恩-朗沐科研发展专项基金项目(ⅡT)(BJ2020IIT001);Alcon资助项目(ⅡT#75019437)。

摘　　要：糖尿病视网膜病变(DR)是工作年龄成年人失明的主要原因,也是糖尿病常见的并发症之一。及时检测和靶向干预可有效地减少DR引起的视力损害。然而,DR早期缺乏典型症状,同时大范围长期眼底筛查又难度大,故导致DR的诊断和治疗延迟。本文中笔者就循环及眼生物液在早期糖尿病视网膜病变筛查和风险分层管理中的研究进展进行综述,旨在为其治疗和预防性干预提供参考。Diabetic retinopathy(DR)is the leading cause of blindness in working-age adults and one of the most common complications of diabetes.Timely detection and targeted intervention can effectively reduce the visual impairment caused by DR.However,the lack of typical symptoms in the early stage and the difficulty of large-scale long-term fundus screening often delayed the diagnosis and treatment of DR.The progress of circulating and ocular biomarkers in screening and risk stratification and management of patients with early diabetic retinopathy were reviewed in this paper,aiming to provide the reference for therapies and preventive interventions.

关 键 词：生物液 生物标志物 早期糖尿病视网膜病变 筛查 管理 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]