血清sFlt-1、Amphiregulin水平联合在预测子痫前期孕妇妊娠结局中的应用价值  

The application value of serum sFlt-1 combined amphiregulin levels in predicting pregnancy outcome of preeclampsia pregnant women

作　　者：张萍萍 苗晶 王志华 ZHANG Pingping;MIAO Jing;WANG Zhihua(The First Department of Production,Zhangjiakou First Hospital,Zhangjiakou,Hebei 075000,China)

机构地区：[1]张家口市第一医院产一科,河北张家口075000

出　　处：《中国优生与遗传杂志》2023年第12期2520-2524,共5页Chinese Journal of Birth Health & Heredity

基　　金：张家口市重点研发计划项目大健康和生物医疗专项(2021106D)。

摘　　要：目的探讨可溶性血管内皮生长因子受体-1(sFlt-1)、双调蛋白(Amphiregulin)在子痫前期孕妇血清中的表达,以及在妊娠结局中的应用价值。方法收集2020年2月至2021年6月张家口市第一医院收治的子痫前期62例患者作为研究对象;另选取同期正常妊娠产妇58例作为对照组。比较各组血清sFlt-1、Amphiregulin水平;分析子痫前期患者血清sFlt-1、Amphiregulin水平分别与24h尿蛋白定量、收缩压、舒张压的相关性;分析血清sFlt-1、Amphiregulin水平对妊娠结局的预测价值。结果对照组、轻度组、重度组血清sFlt-1表达水平依次上升(P<0.05),Amphiregulin表达水平依次下降(P<0.05)。妊娠不良组血清sFlt-1的表达水平高于妊娠良好组(P<0.05);血清Amphiregulin的表达水平低于妊娠良好组(P<0.05)。子痫前期患者血清sFlt-1水平分别与24 h尿蛋白定量、收缩压、舒张压均呈正相关(P<0.05);子痫前期患者血清Amphiregulin水平分别与24h尿蛋白定量、收缩压、舒张压均呈负相关(P<0.05)。sFlt-1、Amphiregulin二者联合预测优于各自单独预测(P<0.05)。结论子痫前期孕妇血清sFlt-1水平升高,Amphiregulin水平降低,二者联合对预测子痫前期患者发生不良妊娠结局有较好的参考价值。Objective To investigate the expression of soluble vascular endothelial growth factor receptor-1(sFlt-1)and Amphiregulin in the serum of pre eclampsia pregnant women,and their application value in pregnancy outcomes.Methods A total of 62 preeclampsia patients admitted to Zhangjiakou First Hospital from February 2020 to June 2021 were collected as research subjects,another 58 normal pregnant women were selected as the control group.The serum levels of sFlt-1 and Amphiregulin in each group were compared.To analyze the correlation between serum levels of sFlt-1 and Amphiregulin in patients with preeclampsia and 24-hour urinary protein quantification,systolic blood pressure,and diastolic blood pressure,respectively.To analyze the predictive value of serum sFlt-1 and Amphiregulin levels on pregnancy outcomes.Results The expression level of sFlt-1 in the serum of the control group,mild group,and severe group increased(P<0.05),while the expression level of Amphiregulin decreased(P<0.05).The expression level of sFlt-1 in the serum of the poor pregnancy group was higher than that of the good pregnancy group(P<0.05),the expression level of Amphiregulin in serum was lower than that in the good pregnancy group(P<0.05).The serum sFlt-1 level in preeclampsia patients was positively correlated with 24-hour urinary protein quantification,systolic and diastolic blood pressure,respectively(P<0.05).The serum Amphiregulin level in patients with preeclampsia was negatively correlated with 24-hour urinary protein quantification,systolic blood pressure,and diastolic blood pressure,respectively(P<0.05).The combined prediction of sFlt-1 and Amphiregulin is superior to their individual predictions(P<0.05).Conclusion The serum level of sFlt-1 in pre eclampsia pregnant women is elevated,and Amphiregulin level is decreased,and the combination of the two has good reference value in predicting adverse pregnancy outcomes in preeclampsia patients.

关 键 词：子痫前期 可溶性血管内皮生长因子受体-1 双调蛋白 妊娠结局 

分 类 号：R714.244[医药卫生—妇产科学]