过敏原特异性Th2细胞表面标志物的研究进展  

Advancements in the study of allergen-specific Th2 cell surface markers

作　　者：门月华[1] 孙鹏海 王文慧[1] 初明[2] Men Yuehua;Sun Penghai;Wang Wenhui;Chu Ming(Dermatology Department of Peking University Third Hospital,Beijing 100191,China;Department of Immunology,Peking University Health Science Center,Beijing 100191,China)

机构地区：[1]北京大学第三医院皮肤科,北京100191 [2]北京大学医学部基础医学院免疫学系,北京100191

出　　处：《中华预防医学杂志》2023年第12期1949-1956,共8页Chinese Journal of Preventive Medicine

基　　金：国家自然科学基金(81603119)。

摘　　要：过敏原特异性Th2细胞指的是一类受到过敏原刺激后大量扩增的Th2细胞亚群,它在过敏性疾病中发挥重要作用,越来越多的研究发现过敏原特异性Th2细胞的表面分子及其与过敏性疾病之间有密切的关系。相比于其他CD4^(+)T细胞或Th2细胞,过敏原特异性Th2细胞低表达CD27,高表达CD154、CD69、CRTH2、CD161、ST2、hPGDs、CD49d、COX-2,它们可作为过敏原特异性Th2细胞的标志,且可作为预防与治疗特异性疾病的潜在靶点,对预防过敏性疾病发病及加重具有重要的价值。Allergen-specific Th2 cells refer to a subset of Th2 cells that undergo substantial expansion following allergen stimulation.They play a crucial role in allergic diseases,and an increasing amount of research has revealed a close relationship between surface molecules on allergen-specific Th2 cells and allergic diseases.In comparison to other CD4^(+)T cells or Th2 cells,allergen-specific Th2 cells exhibit low expression of CD27 but high expression of CD154,CD69,CRTH2,CD161,ST2,hPGDs,CD49d,and COX-2.They can be used for the identification of allergen-specific Th2 cells and serve as potential targets for the prevention and treatment of specific diseases.They hold significant value in preventing the onset and exacerbation of allergic diseases.

关 键 词：过敏性疾病 2型炎症 TH2细胞 过敏原特异性Th2细胞 

分 类 号：R593.1[医药卫生—内科学]