上海市基于社区18~24岁无相关疫苗接种史女性的人乳头瘤病毒感染现况及相关因素分析  

Analysis of the current status and related factors of human papillomavirus infection among community-dwelling women aged 18-24 years without a history of vaccination in Shanghai City

作　　者：段建芳 郭翔[2] 仇静 黄芳 李娟 李智[2] 郑英杰 孙晓冬[2] Duan Jianfang;Guo Xiang;Qiu Jing;Huang Fang;Li Juan;Li Zhi;Zheng Yingjie;Sun Xiaodong(Department of Epidemiology,School of Public Health,Fudan University,Shanghai 200032,China;Department of Immunization,Shanghai Municipal Center for Disease Control and Prevention,Shanghai 200336,China)

机构地区：[1]复旦大学公共卫生学院流行病学教研室,上海200032 [2]上海市疾病预防控制中心免疫规划所,上海200336

出　　处：《中华预防医学杂志》2023年第12期2056-2063,共8页Chinese Journal of Preventive Medicine

基　　金：上海市疾病预防控制青年骨干人才培养项目(22QNGG08)。

摘　　要：目的了解上海市基于社区无相关疫苗接种史年轻女性的人乳头瘤病毒(HPV)感染状况,分析该人群HPV感染的相关因素。方法将2022年7月至2023年2月在上海市36个社区卫生服务中心预约HPV疫苗的2660名18~24岁女性作为研究对象,采用自填式电子问卷收集对象基本情况(包括人口学特征、既往疾病史、女性月经史与生育史和性生活史等);采集对象宫颈分泌物进行HPV核酸分型检测。采用多因素logistic回归模型分析对象高危型HPV(HR-HPV)感染相关因素。结果对象年龄为(23±1)岁,HPV感染率为14.51%(386例),其中HR-HPV和低危型HPV感染率分别为13.53%(360例)和1.84%(49例),HR-HPV感染主要亚型为HPV52、16、58、39和66。多因素logistic回归模型分析显示:与参照组相比,已婚、月收入2000元以下者感染HR-HPV的风险较低,OR(95%CI)值分别为0.41(0.25~0.66)、0.39(0.21~0.70);偶尔饮酒、曾患妇科疾病、过去一年性伴侣数量≥2人、不清楚伴侣是否还有其他的性伴侣者感染HR-HPV的风险较高,OR(95%CI)值分别为1.45(1.13~1.86)、1.29(1.00~1.66)、2.18~5.18(1.02~16.05)和1.82(1.31~2.54)。结论上海市18~24岁社区女性HPV感染率处于较高水平,HR-HPV感染主要亚型为HPV52、16、58、39和66,婚姻状况、经济收入水平、饮酒状况、妇科疾病史和性生活史与HR-HPV感染相关。Objective To understand the status of human papillomavirus(HPV)infection among young women without a history of vaccination in Shanghai,and analyze the related factors of HPV infection in this population.Methods A total of 2660 women aged 18-24 years old who had made an appointment for HPV vaccine at 36 community health service centers in Shanghai from July 2022 to February 2023 were selected as the study subjects.Basic information(including demographic characteristics,previous disease history,female menstrual and reproductive history,sexual life history,etc.)was collected by a self-filling electronic questionnaire.Cervical secretions were detected by HPV nucleic acid typing.The multivariate logistic regression model was used to analyze the factors related to high-risk HPV(HR-HPV)infection in the target population.Results The age of the subjects was(23±1)years old,and the infection rate of HPV was 14.51%(386 cases),among which the infection rates of HR-HPV and low-risk HPV were 13.53%(360 cases)and 1.84%(49 cases),respectively.The main subtypes of HR-HPV infection were HPV52,16,58,39 and 66.The multivariate logistic regression model analysis showed that compared with the control group,the OR(95%CI)values for HR-HPV infection in the group of married,earned less than 2000 yuan/month,drank alcohol occasionally,gynecological disease history,had two or more sexual partners in the past year,and did not know whether the partners had other sexual partners were 0.41(0.25-0.66),0.39(0.21-0.70),1.45(1.13-1.86),1.29(1.00-1.66),2.18-5.18(1.02-16.05),and 1.82(1.31-2.54),respectively.Conclusion The infection rate of HPV among women aged 18-24 years old in Shanghai remains at a high level.The main subtypes of HR-HPV infection are HPV52,16,58,39 and 66.The marital status,economic income level,drinking status,gynecological disease history and sexual life history are related to HR-HPV infection.

关 键 词：子宫颈 感染 人乳头瘤病毒 横断面研究 

分 类 号：R186[医药卫生—流行病学]