2013—2019年云南省农村育龄妇女孕前风疹病毒IgG抗体检测情况的调查分析  

Investigation and analysis on the detection of IgG antibodies against the rubella virus among rural childbearing-age women in preconception period in Yunnan Province from 2013 to 2019

作　　者：谢正媛 曹光 陈涓涓 陈婷婷 孙丽娟 李奕晓 祖维磊 叶峻杰 杜应雄 赵子高 叶汉风 Xie Zhengyuan;Cao Guang;Chen Juanjuan;Chen Tingting;Sun Lijuan;Li Yixiao;Zu Weilei;Ye Junjie;Du Yingxiong;Zhao Zigao;Ye Hanfeng(Population and Family Planning Institute of Yunnan Province/NHC Key Laboratory of Periconception Health Birth in Western China,Kunming 650021,China;Key Laboratory of Medicinal Chemistry for Natural Resource,Ministry of Education,Yunnan University/Yunnan Provincial Center for Research&Development of Natural Products/School of Pharmacy,Yunnan University,Kunming 650500,China)

机构地区：[1]云南省人口和计划生育科学技术研究所国家卫生健康委员会西部孕前优生重点实验室,昆明650021 [2]云南大学自然资源药物化学教育部重点实验室云南省天然产物转化与应用重点实验室云南大学药学院,昆明650500

出　　处：《中华预防医学杂志》2023年第12期2134-2139,共6页Chinese Journal of Preventive Medicine

基　　金：云南省高层次卫生健康技术人才培养专项经费资助(H-2019009);云南省重大科技专项(202002AA100007);云南省科技厅科技计划项目(202101AT070194)。

摘　　要：以2013—2019年云南省接受国家免费孕前优生健康检查的20~49岁农村育龄妇女为研究对象,描述及分析云南省不同人口学特征人群孕前风疹病毒IgG抗体阴性率及其差异。在纳入的1511203名研究对象中,风疹病毒IgG抗体阴性率为24.36%,仅有2.64%人群自我报告曾接种过风疹病毒疫苗。云南省农村育龄妇女孕前风疹病毒IgG抗体阴性率随年龄的增加、文化程度的升高而降低(均P_(趋势)<0.001)。少数民族育龄妇女孕前风疹病毒IgG抗体阴性率(25.19%)高于汉族(23.88%)。在参检人数超过1000名的22个民族中,布朗族(32.85%)、布依族(31.03%)、壮族(31.01%)和苗族(30.70%)育龄妇女风疹病毒IgG抗体阴性率高于其他民族。在云南省16个州(市)中,文山壮族苗族自治州(38.06%)和临沧市(32.63%)育龄妇女孕前风疹IgG抗体阴性率高于其他地区。自我报告曾接种风疹病毒疫苗的妇女血清风疹病毒IgG抗体阴性率(18.60%)低于其他未接种疫苗的人群(24.52%)。云南省农村育龄妇女孕前风疹病毒易感人群占比仍然很高。应促进风疹易感人群,尤其是计划怀孕的妇女的风疹疫苗接种以防止风疹病毒感染、降低风疹人群发病率和疾病负担。A study was conducted on rural women of childbearing age aged 20-49 who underwent the National Free Preconception Health Examination Project(NFPHEP)in Yunnan Province from 2013 to 2019.Descriptive analysis was conducted to determine the negative rate of IgG antibodies against the rubella virus and its differences among various socio-demographic characteristics.Among the 1511203 study subjects,the negative rate of IgG antibodies against the rubella virus was 24.36%.Only 2.64%of the population had received rubella virus vaccine.The negative rate of IgG antibodies among rural childbearing-age women in the preconception period in Yunnan Province decreased with age and educational level(Ptrend<0.001).The negative rate of IgG antibodies in ethnic minority women of childbearing age in the preconception period(25.19%)was higher than that of Han women(23.88%).Among the 22 ethnic groups with over 1000 participants,the negative rates of IgG antibodies in women of childbearing age from the Blang(32.85%),Bouyei(31.03%),Zhuang(31.01%),and Miao(30.70%)ethnic groups were higher than those of women from other ethnic groups.Among the 16 states(cities)in Yunnan Province,the negative rate of IgG antibodies in pregnant women of childbearing age in Wenshan Zhuang and Miao Autonomous Prefecture(38.06%)and Lincang City(32.63%)was higher than that in other states(cities).The negative rate of serum IgG antibodies in women who reported having received rubella virus vaccine(18.60%)was lower than that in other non-vaccinated populations(24.52%).The proportion of rural women of childbearing age in Yunnan Province who were susceptible to the rubella virus before pregnancy was still high.It is necessary to promote rubella vaccination among people susceptible to rubella,especially pregnant women,to prevent rubella virus infection and reduce the incidence rate and disease burden of rubella people.

关 键 词：风疹病毒 IGG抗体 少数民族 育龄妇女 农村地区 

分 类 号：R446.6[医药卫生—诊断学]