结核分枝杆菌ESX-5分泌系统的研究进展  

Research progress on ESX-5 secretion system of Mycobacterium tuberculosis

作　　者：余海燕(综述) 杨国平(审校) YU Haiyan;YANG Guoping(Department of Microbiology and Immunology,School of Medicine,Dali University,Dali 671000,Yunnan,China)

机构地区：[1]大理大学基础医学院医学微生物学及免疫学教研室,大理671000

出　　处：《医学研究与战创伤救治》2023年第11期1207-1211,共5页Journal of Medical Research & Combat Trauma Care

基　　金：云南省地方本科高校联合专项面上项目(2017FH001-085);大理大学高层次人才资助项目(KYBS201708)。

摘　　要：ESX-5分泌系统是结核分枝杆菌(Mtb)的ESX分泌系统中最晚进化形成的,仅存于生长缓慢的致病性分枝杆菌中,是Mtb营养吸收和维持膜渗透性所需的基本分泌系统,也是Mtb与宿主相互作用的重要调节剂,并参与PE/PPE家族蛋白的运输与分泌、对维持Mtb细胞壁的完整性和毒力的发挥具有重要作用。文章对Mtb ESX-5分泌系统的组成与结构、分泌机制及作用进行综述,以期为进一步解析Mtb的ESX-5分泌系统,研发抗结核疫苗提供新的思路。The ESX-5 secretory system is the latest evolution of the ESX secretory system of Mycobacterium tuberculosis(Mtb),and only exists in the slow-growing pathogenic mycobacterium.It is the basic secretory system required for nutrient absorption and membrane permeability maintenance of Mtb,and it is also an important regulator of the interaction between Mtb and host.It is in-volved in the transport and secretion of PE/PPE family proteins and plays an important role in maintaining the integrity and virulence of Mtb cell wall.This paper reviews the composition,structure,secretion mechanism and function of Mtb ESX-5 secretory systemin order to provide new ideas for further analysis of Mtb ESX-5 secretory system and development of anti-tuberculosis vaccine.

关 键 词：结核分枝杆菌 ESX-5分泌系统 ESX分泌系统 

分 类 号：R378.91[医药卫生—病原生物学]