基于古今医案云平台探究青光眼视神经保护用药规律  

To Explore the Medication Rule of Glaucoma Optic Nerve Protection Based on the Ancient and Modern Medical Record Cloud Platform

作　　者：朱丽颖 黎晓冬 谢学军[2] Zhu Liying;Li Xiaodong;Xie Xuejun(Chengdu University of TCM,Chengdu 610075,China;The Hospital Affiliated to Chengdu University of TCM,Chengdu 610072,China)

机构地区：[1]成都中医药大学,四川1成都610075 [2]成都中医药大学附属医院,四川成都3610072

出　　处：《亚太传统医药》2024年第1期189-193,共5页Asia-Pacific Traditional Medicine

基　　金：成都中医药大学学科创新团队项目(XKTD2022005)。

摘　　要：目的:应用古今医案云平台软件(V2.3.5)分析青光眼视神经保护用药规律。方法:检索中国知网数据库(CNKI)、万方数据库(WanFang)、维普数据库(VIP)中已公开发表的青光眼相关研究文献。提取数据并建立处方数据库,采用古今医案云平台软件(V2.3.5)分析数据。结果:(1)一般情况:最终纳入文献70篇,包含方剂70个,涉及中药134味、中医证候15个。四气以平性药最多(24.78%),五味以甘味药最多(59.09%),归经以肝经用药最多(59.21%)。(2)使用频次:频次≥20次的中药中排名前5味的分别为茯苓、当归、川芎、白术和柴胡。(3)中医证候:排在前5位的分别为肝肾阴虚证、肝郁气滞证、气虚血瘀证、肝肾亏虚证、气阴两虚证。(4)中药配伍关联分析:相关度排在前5位的分别为当归-茯苓、川芎-当归、白术-茯苓、白术-当归、柴胡-茯苓。(5)聚类分析:药对与方剂共5类,其功效分别为补血活血、疏肝利水、补气、补益肝肾、活血利水。(6)复杂网络分析:核心处方为丹栀逍遥散加减。结论:临床对于青光眼辨证施方应疏肝与活血利水并重,用药当以主入肝经的性平味甘类中药为佳,临证中应活用核心药物,注重组方君臣佐使配伍,达到保护视神经的目的。Objective:To analyze the medication pattern of optic nerve protection in glaucoma by applying the ancient and modern medical case cloud platform software(V2.3.5).Methods:Glaucoma-related research literature published in the China Knowledge Network database(CNKI),Wanfang database(WanFang),and VIP database(VIP)database were retrieved.The data were extracted,and a prescription database was established,and the data were analyzed using the Ancient Medical Case Cloud Platform software(V2.3.5).Results:①General:70 articles containing 70 prescrip-tions involving 134 Chinese herbs and 15 TCM symptoms were finally included in the literature.The four qi were most frequently used by ping(24.78%),the five flavors were most frequently used by sweet(59.09%),and the liver merid-ian was most frequently used by the liver meridian(59.21%).②Frequency of use:The top 5 herbs with frequency≥20 times were Fuling,Angelica sinensis,Chuanxiong,Atractylodes macrocephala and Chaihu.③TCM symptoms:the top 5 were liver and kidney yin deficiency,liver depression and Qi stagnation,Qi deficiency and blood stasis,liver and kidney deficiency,and Qi and Yin deficiency,respectively.④Analysis of the correlation between Chinese herbal medicine pair-ings:the top 5 correlations were Angelica-Fuling;Chuanxiong-Angelica;Baizhu-fuling;Baizhu-Angelica and Chaihu-Fuling.⑤Cluster analysis:There are 5 categories of drug pairs and formulas,whose effects are tonifying the blood and in-vigorating the blood,draining the liver and promoting diuresis,tonifying the Qi,tonifying the liver and kidney,and invig-orating the blood and promoting diuresis.⑥Complex network analysis:the core prescription Danzhi Xiaoyao powder plus or minus.Conclusion:The clinical prescriptions for glaucoma should give equal importance to dredging the liver and invigorating the blood to promote diuresis,and the drugs used should be those with a flat nature and sweet taste that mainly enter the liver meridian,and the core drugs should be used in the clinical evidence,and the combinat

关 键 词：青光眼 视神经保护 组方规律 数据挖掘 

分 类 号：R276.7[医药卫生—中医五官科学]