基于薄膜壳体理论的仿淋巴瓣膜结构设计  

Design of bionic lymphatic valve structure based on membrane shell theory

作　　者：左少华 丁来钱 李扬 陈莉[1,2] 李经民[1,2] 刘冲[1,2] ZUO Shaohua;DING Laiqian;LI Yang;CHEN Li;LI Jingmin;LIU Chong(School of Mechanical Engineering,Dalian University of Technology,Dalian 116024,China;Key Laboratory for Micro/Nano Technology and Systems of Liaoning Province,Dalian University of Technology,Dalian 116024,China)

机构地区：[1]大连理工大学机械工程学院,辽宁大连116024 [2]大连理工大学辽宁省微纳米技术及系统重点实验室,辽宁大连116024

出　　处：《传感器与微系统》2024年第2期72-75,共4页Transducer and Microsystem Technologies

基　　金：国家自然科学基金资助项目(51875084);中央高校基本科研业务费资助项目(DUT20YG102,DUT20ZD103)。

摘　　要：淋巴系统中的瓣膜结构是控制淋巴液单向流动的关键结构,进而影响肿瘤细胞的淋巴转移过程。基于薄膜壳体理论设计了仿淋巴瓣膜结构,通过COMSOL有限元仿真分析了瓣膜厚度、弹性对其变形的影响。配制了聚二甲基硅氧烷(PDMS)与Ecoflex00—30的混合材料,通过调整二者的体积比,使其杨氏模量与生物组织实际值更接近。采用软刻蚀技术制作了仿淋巴管微通道,测试了其单向截流性能。结果表明:在80 Pa压力下,仿淋巴瓣膜结构无明显漏液现象,单向截流性能良好。The lymphatic valve is a critical structure that control flowing of the lymph fluid,and further affects the tumor lymphatic metastasis.The bionic lymphatic valve structure is designed based on the membrane shell theory,and the effects of thickness and elasticity of the valve on its deformation are simulated and analyzed with COMSOL finite element simulation.A mixed material is prepared with PDMS and Ecoflex00-30,by adjusting volume ratio of the two materials,making its Young’s modulus more closer to the native tissue.The microchannel with the bionic lymphatic vessel is fabricated by the soft-etching technique,one-way closure performance is tested.The results show that under the pressure of 80 Pa,there is no obvious leakage in bionic lymphatic vessel structure,one-way closure performance is good.

关 键 词：淋巴瓣膜 薄膜壳体理论 流固耦合 杨氏模量 

分 类 号：TP212[自动化与计算机技术—检测技术与自动化装置] TH162[自动化与计算机技术—控制科学与工程] Q811.6[机械工程—机械制造及自动化]