孕中期双胎妊娠孕妇血清E2、P、β-HCG联合检测对母婴结局的判断价值分析  

Analysis of the value of combined detection of serum E2,P,andβ-HCG in pregnant wom-en with twin pregnancies in the second trimester to determine maternal and fetal outcomes

作　　者：董丹[1] 杜娜[2] 董倩[1] 郭亮[3] DONG Dan;DU Na;DONG Qian;GUO Liang(Department of Obstetrics and Gynecology Center,the First Hospital of Jilin University,Changchun,Jilin,China,130021;Department of Infectious Diseases,the First Hospital of Jilin University,Changchun,Jilin,China,130021;Department of Pathology,the First Hospital of Jilin University,Changchun,Jilin,China,130021)

机构地区：[1]吉林大学第一医院妇产中心,吉林长春130021 [2]吉林大学第一医院感染科,吉林长春130021 [3]吉林大学第一医院病理科,吉林长春130021

出　　处：《分子诊断与治疗杂志》2023年第12期2088-2091,2096,共5页Journal of Molecular Diagnostics and Therapy

基　　金：吉林省科技厅重点研发项目(20220404209YY)。

摘　　要：目的探讨孕中期双胎妊娠孕妇血清雌二醇(E_(2))、孕酮(P)、β-人绒毛膜促性腺激素(β-HCG)联合检测对母婴结局的判断价值分析。方法回顾性选取2018年6月至2021年3月在吉林大学第一医院接受正规产检的孕中期双胎妊娠孕妇60例纳入双胎组,另选取同期在本院产检的孕中期单胎妊娠孕妇98名纳入单胎组,对比两组孕妇孕中期血清E_(2)、P、β-HCG水平,根据母体及胎儿结局将双胎组划分为母体及胎儿正常亚组、母体不良亚组与胎儿不良亚组,采用Spearman分析双胎组孕妇孕中期血清E_(2)、P、β-HCG水平与母婴结局的相关性;绘制受试者工作特征曲线(ROC)分析孕中期血清E_(2)、P、β-HCG水平单一及联合检测对双胎妊娠母体、胎儿不良结局的预测价值,并计算曲线下面积(AUC)。结果双胎组孕妇孕中期血清β-HCG、E_(2)、P水平均高于单胎组孕妇,差异有统计学意义(P<0.05);血清β-HCG、E_(2)、P水平:母体及胎儿正常亚组>母体不良亚组>胎儿不良亚组,差异具体统计学意义(P<0.05)。母体不良结局、胎儿不良结局与孕妇孕中期血清β-HCG、E_(2)、P水平具有较高负相关性(P<0.05)。孕中期血清E_(2)、P、β-HCG三者联合预测母体、胎儿不良结局的AUC分别为0.963、0.853,均高于血清E_(2)、P、β-HCG单项检测(P<0.05)。结论双胎妊娠孕妇孕中期血清E_(2)、P、β-HCG水平高于单胎妊娠,双胎妊娠母婴不良结局风险随着孕妇血清E_(2)、P、β-HCG水平的异常降低而增大,三者联合检测可提高预测母体、胎儿不良结局的概率。Objective To investigate the diagnostic value of serum estradiol(E_(2)),progesterone(P)andβ-HCG combined detection in pregnant women during the second trimester of pregnancy.Methods 60 pregnant women with twin pregnancies in the second trimester who received regular birth examination at the First Hospital of Jilin University from June 2018 to March 2021 were retrospectively selected to be included in the twin group,another 98 pregnant women with single pregnancies in the second trimester who received birth examination in our hospital during the same period were selected to be included in the single group,Serum E_(2),P,β-HCG levels of pregnant women in the second trimester were compared between the two groups,according to the delivery outcome,the twin groups were divided into the normal maternal and fetal subgroups,poor maternal subgroups and poor fetal subgroups,Spearman was used to analyze the correlation between serum E_(2),P,β-HCG levels and maternal and infant outcomes in the second trimester of the twin group.The receiver operating characteristic curve(ROC)was drawn to analyze the predictive value of single and combined detection of serum E_(2),P,andβ-HCG levels in the second trimester for maternal and fetus adverse outcomes in twin pregnancies,and the area under the curve(AUC)was calculated.Results The serumβ-HCG,E_(2),and P levels in the second trimester of pregnancy in the twin group were higher than those in the single group,and the difference was statistically significant(P<0.05).The levels of serumβ-HCG,E_(2)and P:normal maternal and fetal subgroups>poor maternal subgroups>poor fetal subgroups,with specific statistical significance(P<0.05).Maternal adverse outcomes and fetal adverse outcomes were negatively correlated with serum levels ofβ-HCG,E_(2)and P in pregnant women in the second trimester(P<0.05).The AUC of serum E_(2),P,andβ-HCG in the second trimester to jointly predict maternal and fetus adverse pregnancy outcomes were 0.963 and 0.853 respectively,both of which were higher than serum

关 键 词：双胎妊娠 孕中期 血清雌二醇 孕酮 Β-HCG 

分 类 号：R714.23[医药卫生—妇产科学]