慢性乙型肝炎患者乙肝病毒基因分型和病毒载量的相关性及临床意义  

Correlation and clinical significance of hepatitis B virus genotype and viral load in patients with chronic hepatitis B

作　　者：刘明 卞成蓉 杨宁 张旺 杨光 徐军 苏银亮 刘学迪 李伯安 LIU Ming;BIAN Chengrong;YANG Ning;ZHANG Wang;YANG Guang;XU Jun;SU Yinliang;LIU Xuedi;LI Boan(Department of Clinical Laboratory,the Fifth Medical Center,Chinese People's Liberation Army(PLA)General Hospital,Beijing,China,100039)

机构地区：[1]中国人民解放军总医院第五医学中心检验科,北京100039

出　　处：《分子诊断与治疗杂志》2023年第12期2159-2162,共4页Journal of Molecular Diagnostics and Therapy

摘　　要：目的探讨乙肝病毒基因分型和乙肝病毒载量及临床表现的关系。方法选取中国人民解放军总医院第五医学中心2019年1月至2021年12月收治的乙型肝炎患者600例,统计分析患者采用荧光PCR的方法进行乙肝病毒基因分型和HBV DNA载量。结果根据病毒基因分型结果显示,B型123例(20.5%),C型447例(74.5%),B/C混合型2例(0.3%),非B非C型28例(4.7%)。HBV DNA载量结果显示,C型HBV DNA水平较B型显著增高,C型患者肝硬化、原发性肝癌与B型患者比较,差异有统计学意义(χ^(2)=10.75,P<0.05);C型HBV DNA水平明显高于B型,差异有统计学意义(P<0.05)。结论感染HBV基因型以C型为主,C型HBV DNA水平显著高于B型,C型较B型对肝脏损伤大。Objective To explore the relationship between hepatitis B virus genotype and hepatitis B virus load and clinical manifestations.Methods 600 patients with hepatitis B admitted to the Fifth Medical Center of the General Hospital of the Chinese People's Liberation Army from January 2019 to December 2021 were selected.The patients were statistically analyzed for hepatitis B virus genotyping and HBV DNA load by fluorescent PCR.Results According to the results of viral genotyping,123 cases(20.5%)were type B,447 cases(74.5%)were type C,2 cases(0.3%)were mixed type B/C,and 28 cases(4.7%)were non-B non-C.The HBV DNA load results showed that the level of HBV DNA in genotype C was significantly higher than that in genotype B,and there was a significant difference in the incidence of cirrhosis and primary liver cancer between genotype C and B patients(χ^(2)=10.75,P<0.05).The level of HBV DNA in type C was significantly higher than that in type B,with a statistically significant difference(P<0.05).Conclusion The most common genotype of HBV infection is genotype C,and the level of HBV DNA in genotype C is significantly higher than that in genotype B.Genotype C has a greater impact on liver injury than genotype B.

关 键 词：乙型肝炎病毒 基因分型 病毒载量 

分 类 号：R512.62[医药卫生—内科学]