妊娠期高血压疾病患者血清hs-CRP、sFlt-1水平变化及与妊娠结局的相关性  

Changes in Serum hs-CRP and sFlt-1 Levels in Patients with Hypertensive Disorders of Pregnancy and Their Correlation with Pregnancy Outcomes

作　　者：王燕枚 黄婷 胡娟娟 WANG Yanmei;HUANG Ting;HU Juanjuan(Obstetrical Department,Ganzhou Maternal and Child Health Hospital,Ganzhou 341000,China;不详)

机构地区：[1]赣州市妇幼保健院产科,江西赣州341000

出　　处：《中国医学创新》2024年第3期1-5,共5页Medical Innovation of China

基　　金：江西省卫生健康委员会科技计划项目(202312045)。

摘　　要：目的:探讨妊娠期高血压疾病(HDP)患者血清可溶性血管内皮生长因子受体-1(sFlt-1)、超敏C反应蛋白(hs-CRP)水平变化及与妊娠结局的相关性。方法:收集2022年1月—2023年2月于赣州市妇幼保健院接受治疗的HDP患者108例作为病例组,并进行回顾性分析。根据病情严重程度将病例组患者分为妊娠期高血压组(43例)、子痫前期组(35例)、子痫组(30例),并选取同期正常妊娠的妇女82例作为对照组。分析所有研究对象中血清hs-CRP、sFlt-1水平变化情况。结果:病例组血清hs-CRP、sFlt-1水平均明显高于对照组(P<0.05)。妊娠期高血压组、子痫前期组、子痫组患者血清hs-CRP、sFlt-1水平比较差异均有统计学意义(P<0.05),且血清hs-CRP、sFlt-1水平随病情严重程度的加重而升高(P<0.05)。不良妊娠结局组患者血清hs-CRP、sFlt-1水平均高于妊娠结局良好组(P<0.05)。血清hs-CRP、s Flt-1水平反映HDP患者妊娠结局的AUC分别为0.758、0.763。相关性分析显示,hs-CRP、sFlt-1之间呈正相关(r=0.743,P<0.001)。结论:HDP患者血清中hs-CRP、sFlt-1水平均升高,且随疾病严重程度的加重而增加,并与妊娠结局有一定的相关性。Objective:To investigate the changes of serum soluble fms-like tyrosine kinase receptor 1(sFlt-1) and hypersensitive C reactive protein(hs-CRP) levels and their correlation with pregnancy outcomes in patients with hypertensive disorders of pregnancy(HDP).Method:One hundred and eight HDP patients who received treatment in Ganzhou Maternal and Child Health Hospital from January 2022 to February 2023 were collected as a case group and analyzed retrospectively.According to the severity of the disease,the patients in the case group were divided into gestational hypertension group(43 cases),preeclampsia group(35 cases) and eclampsia group(30 cases),and 82 women with normal pregnancy during the same period were selected as the control group.The changes of serum hs-CRP and sFlt-1 levels in all subjects were analyzed.Result:The serum levels of hs-CRP and sFlt-1 in case group were significantly higher than those in control group(P<0.05).There were significant differences in serum hs-CRP and sFlt-1 levels among gestational hypertension group,preeclampsia group and eclampsia group(P<0.05),and the serum hs-CRP and sFlt-1 levels increased with the severity of the disease(P<0.05).The levels of hs-CRP and sFlt-1 in the adverse pregnancy outcome group were higher than those in the good pregnancy outcome group(P<0.05).The AUC values of serum hs-CRP and sFlt-1 reflecting pregnancy outcome in patients with HDP were 0.758and 0.763,respectively.Correlation analysis showed that hs-CRP and sFlt-1 were positively correlated(r=0.743,P<0.001).Conclusion:The serum levels of hs-CRP and sFlt-1 in patients with HDP increase and increase with the severity of the disease,and have a certain correlation with pregnancy outcome.

关 键 词：妊娠期高血压疾病 妊娠结局 可溶性血管内皮生长因子受体-1 超敏C反应蛋白 

分 类 号：R714.246[医药卫生—妇产科学]