急性心肌梗死患者PCI术前FDP水平对术中慢/无复流的预测价值  

Predictive value of preoperative FDP level on slow/no reflow during PCI of patients with acute myocardial infarction

作　　者：杨帆 田富云 孙君 杨丽 张莉[1] YANG Fan;TIAN Fuyun;SUN Jun;YANG Li;ZHANG Li(Department of laboratory medicine,Zhengzhou Seventh People's Hospital,Zhengzhou,Henan,China,450000)

机构地区：[1]郑州市第七人民医院检验科,河南郑州450000

出　　处：《分子诊断与治疗杂志》2024年第1期19-22,共4页Journal of Molecular Diagnostics and Therapy

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20210743)。

摘　　要：目的研究急性心肌梗死(AMI)患者经皮冠状动脉介入术(PCI)前纤维蛋白原降解产物(FDP)水平对术中慢/无复流的预测价值。方法选择2021年1月至2022年10月在郑州市第七人民医院接受急诊PCI的AMI患者作为研究对象,根据术中是否发生慢/无复流分为慢/无复流组和对照组,术前检测生化指标、FDP、D-二聚体(D-D)、白介素-6(IL-6)、白介素-17(IL-17)。比较两组间各项指标的差异,采用logistic回归模型分析慢/无复流的影响因素,采用ROC曲线分析慢/无复流的预测指标。结果慢/无复流组与对照组的各项生化指标比较差异无统计学意义(P>0.05);慢/无复流组的术前FDP、D-D、IL-6、IL-17均高于对照组,差异有统计学意义(t=7.468、6.070、16.668、8.182,P<0.05);慢/无复流组的术前FDP、D-D水平与IL-6、IL-17水平呈正相关(P<0.05);FDP、D-D、IL-6、IL-17均是发生慢/无复流的影响因素(P<0.05);FDP联合D-D对PCI术中慢/无复流具有良好的预测价值(P<0.05)。结论术前FDP升高与AMI患者急诊PCI术中发生慢/无复流相关,FDP联合D-D检测对慢/无复流具有预测价值。Objective To study the predictive value of preoperative fibrinogen degradation prod-uct(FDP)on slow/no reflow during percutaneous coronary intervention(PCI)of patients with acute myocardial infarction(AMI).Methods AMI patients who received emergency PCI in Zhengzhou Seventh People's Hospital from January 2021 to October 2022 were divided into the slow/no reflow group and the control group according to intraoperative slow/no reflow.Preoperative biochemical parameters,FDP,D-dimer(D-D),interleukin-6(IL-6),interleukin-17(IL-17)were detected,the differences of each indicator between the 2 groups were compared,the influencing factors of slow/no reflow were analyzed by the logistic regression model and the predictors of slow/no reflow were analyzed by the ROC curve.Results There was no significant difference in biochemical parameters between the slow/no reflow group and the control group(P>0.05).Preoperative FDP,D-D,IL-6 and IL-17 in the slow/no reflux group were higher than those in the control group(t=7.468,6.070,16.668,8.182,P<0.05).Preoperative FDP and D-D levels positively correlated with IL-6 and IL-17 in the slow/no reflow group(P<0.05).FDP,D-D,IL-6 and IL-17 were influencing factors of slow/no reflow(P<0.05).FDP and D-D had good predictive value of slow/no reflow during PCI(P<0.05).Conclusion The increased preoperative FDP is associated with slow/no reflow during emergency PCI of AMI patients,and FDP combined with D-D test has predictive value for slow/no reflow.

关 键 词：急性心肌梗死 经皮冠状动脉介入术 慢/无复流 纤维蛋白原降解产物 D-二聚体 预测 

分 类 号：R542.22[医药卫生—心血管疾病]