妊娠晚期血清DBP、25(OH)D表达与新生儿湿疹的相关性  

Correlation between serum DBP and 25(OH)D expression in late pregnancy and neona-tal eczema

作　　者：许红蕊 兰昕祎 魏敬艳 刘瑶[1] 史少文 兰桂清 XU Hongrui;LAN Xinyi;WEI Jingyan;LIU Yao;SHI Shaowen;LAN Guiqing(Department of Obstetrics and Gynecology,Qinhuangdao First Hospital,Qinhuangdao,Hebei,China,066000;Hebei University of Science and Technology,Tangshan,Hebei,China,063000;Department of Inspection,Qinhuangdao Quality and Technical Supervision and Inspection Institute,Qinhuangdao,Hebei,China,066000)

机构地区：[1]秦皇岛市第一医院产科,河北秦皇岛066000 [2]河北科技学院,河北唐山063000 [3]秦皇岛市质量技术监督检验所检验科,河北秦皇岛066000

出　　处：《分子诊断与治疗杂志》2024年第1期102-105,共4页Journal of Molecular Diagnostics and Therapy

基　　金：秦皇岛市科学技术研究与发展计划项目(202004A121)。

摘　　要：目的分析妊娠晚期母亲血清维生素D结合蛋白(DBP)、25-羟基维生素D[25(OH)D表达水平与新生儿湿疹的相关性。方法选取2018年1月至2019年12月秦皇岛市第一医院的产妇及其娩出的新生儿临床资料,从中选取48例新生儿湿疹患儿纳入湿疹组,另选取48名未发生湿疹的健康新生儿纳入健康组,对比两组新生儿母亲妊娠晚期血清DBP、25(OH)D表达水平。采用二元Logistic回归分析新生儿湿疹发生的影响因素;采用受试者工作特征(ROC)曲线分析母亲妊娠晚期血清25(OH)D、DBP表达水平对新生儿湿疹的诊断价值,获取曲线下面积(AUC),置信区间、敏感度、特异性;采用Spearman法分析母亲妊娠晚期血清DBP、25(OH)D表达水平与新生儿湿疹发生的相关性。结果湿疹组母亲血清DBP、25(OH)D表达水平均低于健康组母亲,差异有统计学意义(P<0.05);母亲妊娠晚期血清25(OH)D、DBP诊断新生儿湿疹的AUC分别为0.908、0.884(P<0.05);母亲妊娠晚期血清DBP、25(OH)D低表达均为新生儿湿疹的危险因素(P<0.05);母亲妊娠晚期血清DBP、25(OH)D表达水平与新生儿湿疹的发生负相关(r=-0.665、-0.707,P<0.05)。结论妊娠晚期母亲血清DBP、25(OH)D的表达水平与新生儿湿疹的发生具有相关性,新生儿湿疹的发生风险随着母亲妊娠晚期血清DBP、25(OH)D表达水平的降低而升高,因此,应充分重视孕妇维生素D补充,保证孕妇与胎儿维生素D营养充足,以有效预防新生儿湿疹的发生。Objective To analyze the correlation between the expression levels of serum vitamin D-binding protein(DBP),25-hydroxyvitamin D[25(OH)D]and neonatal eczema.Methods Clinical data of pregnant women and newborns delivered from the First Hospital of Qinhuangdao City from January 2018 to December 2019 were retrospectively analyzed.48 neonates with eczema were selected to be included in the eczema group,and 48 healthy neonates without eczema were selected to be included in the healthy group.Serum DBP and 25(OH)D expression levels of neonatal mothers in the late pregnancy of neonatal mothers were compared between the two groups.Binary logistic regression was used to analyze the influencing factors of neonatal eczema.The receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of maternal serum 25(OH)D and DBP expression levels in late pregnancy for neonatal eczema,and the area under the curve(AUC),confidence interval,sensitivity,and specificity were obtained.The spearman method was used to analyze the correlation between maternal serum DBP and 25(OH)D expression levels in late pregnancy and the occurrence of neonatal eczema.Results The expression levels of DBP and 25(OH)D in serum of mothers in the eczema group were lower than those in the healthy group,with statistical significance(P<0.05).The AUC of serum 25(OH)D and DBP in neonatal eczema were 0.908 and 0.884(P<0.05),respectively.Low levels of DBP and 25(OH)D in maternal serum during the third trimester were risk factors for neonatal eczema(P<0.05).The expression levels of DBP and 25(OH)D in maternal serum during late pregnancy were negatively correlated with the development of neonatal eczema(r=-0.665,-0.707,P<0.05).Conclusion The expression levels of maternal serum DBP and 25(OH)D in late pregnancy are correlated with the occurrence of neonatal eczema,the risk of neonatal eczema increases with the decrease in maternal serum DBP and 25(OH)D expression levels in late pregnancy,therefore,full attention should be paid to vitamin D supplementa

关 键 词：妊娠晚期 维生素D 新生儿湿疹 维生素D结合蛋白 25-羟基维生素D 

分 类 号：R722.1[医药卫生—儿科]