颅脑损伤术后颅脑感染血清NLRP3、SAA及NFκB的临床意义  

Expression and clinical significance of NLRP3,SAA and NFκB in serum of patients with craniocerebral infection after craniocerebral injury

作　　者：黄志美[1] 孙燕宁 何霜霜 HUANG Zhimei;SUN Yanning;HE Shuangshuang(Department of Neurosurgery,Rugao People's Hospital,Rugao,Jiangsu,China,226500)

机构地区：[1]江苏省如皋市人民医院神经外科,江苏如皋226500

出　　处：《分子诊断与治疗杂志》2024年第1期191-194,共4页Journal of Molecular Diagnostics and Therapy

基　　金：江苏省科技项目(BK20201119);南通市基础研究和民生科技计划指导性项目(MSZ21031)。

摘　　要：目的探讨血清寡聚化结构域样受体蛋白3(NLRP3)、淀粉样蛋白A(SAA)及核转录因子(NFκB)在颅脑损伤术后颅脑感染中的诊断价值。方法选择2020年6月至2022年6月江苏省如皋市人民医院接诊的70例颅脑损伤患者为研究对象,根据感染情况将感染者设为感染组(n=19),未感染者设为对照组(n=51),分析血清NLRP3、SAA及NFκB在颅脑损伤术后颅脑感染中的诊断价值。结果感染组患者血清NLRP3、SAA及NFκB水平显著高于对照组,差异有统计学意义(P<0.05);NLRP3、SAA及NFκB水平:轻度感染<中度感染<重度感染,差异有统计学意义(P<0.05);预后不良组患者血清NLRP3、SAA及NFκB水平显著高于预后良好组,差异有统计学意义(P<0.05);ROC结果显示,血清NLRP3预测颅脑损伤术后颅脑感染的AUC为0.634,灵敏度为63.43%,特异度为67.40%,截断值为114.02 pg/mL;血清SAA预测颅脑损伤术后颅脑感染的AUC为0.715,灵敏度73.50%,特异度为69.00%,截断值为30.99 mg/L;血清NFκB预测颅脑损伤术后颅脑感染的AUC为0.914,灵敏度为81.40%,特异度为70.00%,截断值为38.27μg/mL,联合检测较单独检测特异度、准确度更高(P<0.05)。结论血清NLRP3、SAA及NFκB在颅脑损伤术后颅脑感染患者中均异常高表达,且三指标联合检测颅脑损伤术后颅脑感染诊断效能更高,临床应用价值高。Objective To study expression and clinical significance of NOD-like receptor protein 3(NLRP3),Amyloid A(SAA)and Nuclear Transcription factor(NF-κB)in serum of patients with craniocerebral infection after craniocerebral injury.Methods 70 patients with craniocerebral injury admitted to the People's Hospital of Rugao City,Jiangsu Province from June 2020 to June 2022 were selected as the study subjects.They were divided into an infected group(n=19)based on their infection status,and an uninfected group(n=51)as the control group.Serum NLRP3,SAA,and NF were analyzedκThe diagnostic value of B in postoperative craniocerebral infection after craniocerebral injury surgery.Results The levels of NLRP3,SAA and NFκB in infected group were significantly higher than those in control group,and the difference was statistically significant(P<0.05).NLRP3,SAA and NFκB levels were statistically significant in patients with mild infection<moderate infection<severe infection(P<0.05).The levels of NLRP3,SAA and NFκB in poor prognosis group were significantly higher than those in good prognosis group,and the difference was statistically significant(P<0.05).ROC results showed that the AUC of serum NLRP3 was 0.634,the sensitivity was 63.43%,the specificity was 67.40%,and the cut-off value was 114.02 pg/mL.The AUC of serum SAA for predicting craniocerebral infection after craniocerebral injury was 0.715,the sensitivity was 73.50%,the speci-ficity was 69.00%and the cut-off value was 30.99 mg/L.The AUC of serum NFκB for predicting craniocerebral infection after craniocerebral injury was 0.914,the sensitivity was 81.40%,the specificity was 70.00%,and the truncation value was 38.27μg/mL.The specificity and accuracy of combined detection were higher than that of single detection(P<0.05).Conclusion Serum NLRP3,SAA and NFκB are all abnormally high in patients with craniocerebral infection after craniocerebral injury,and the combined detection of craniocerebral infection after craniocerebral injury has higher diagnostic efficacy.This study a

关 键 词：寡聚化结构域样受体蛋白3 淀粉样蛋白A 核转录因子 颅脑损伤 颅脑感染 

分 类 号：R651.15[医药卫生—外科学]