隐球菌临床分离株分子流行病学及抗真菌药物敏感性的研究进展  

Molecular epidemiology and antifungal susceptibility of clinical Cryptococcus

作　　者：范人菲(综述) 方娟 张学东(审校) FAN Renfei;FANG Juan;ZHANG Xuedong(Clinical Research Department,Autobio Diagnostics Co.,Ltd.,Zhengzhou 450000,Henan Province,China)

机构地区：[1]郑州安图生物工程股份有限公司临床科研部,河南郑州450000

出　　处：《微生物学免疫学进展》2023年第6期85-89,共5页Progress In Microbiology and Immunology

摘　　要：隐球菌(Cryptococcus)是一种条件致病性真菌,可造成人类严重感染,具有较大的疾病负担。早期给予合理的抗真菌治疗可直接影响患者的治疗结果。抗真菌药物敏感性试验是检测抗菌药耐药性的重要工具,可为抗菌药的选择提供参考、指导治疗。不同基因型隐球菌的地理分布及抗真菌药物敏感性存在一定差异,了解其流行病学对于监测感染现状、改进隐球菌病的诊断及治疗措施、推动隐球菌病研究的发展具有重要意义。现就隐球菌临床分离株的分子流行病学、抗真菌药物敏感性研究作一概述。Cryptococcus is an opportunistic fungal pathogen causing seriously infections in human with a significant clinical burden.Early initiation of the appropriate antifungal therapy has a direct impact on the patients'outcome.Antifungal susceptibility tests have become essential tools to identify resistance to antifungal,to provide reference for the selection of antibiotics,to reduce inappropriate treatment and to guide the treatment.The geographical distribution and antifungal susceptibility of Cryptococcus are different among different genotypes.It is important to understand the epidemiology of Cryptococcus for monitoring the status of infection,improving future diagnoses and therapies,and driving research efforts associated with cryptococcosis.This study will review the molecular epidemiology and antifungal susceptibility of clinical Cryptococcus.

关 键 词：隐球菌 分子分型 分子流行病学 抗真菌药物敏感性 

分 类 号：R373.2[医药卫生—病原生物学]