肌注二巯基丙磺酸钠和口服二巯丁二酸胶囊治疗慢性砷中毒患者的临床疗效  

Clinical Efficacy of Intramuscular Injection of Sodium Dimercaptosulfonate and Oral Administration of Dimercaptosuccinic Acid Capsules in the Treatment of Patients with Chronic Arsenic Poisoning

作　　者：杨翊梅 黄蕾 吴智敏 赖燕 洪伦 袁娟 YANG Yimei;HUANG Lei;WU Zhimin(Hunan Prevention and Treatment Institute for Occupational Disease,Changsha Hunan 410007)

机构地区：[1]湖南省职业病防治院,湖南长沙410007

出　　处：《医学临床研究》2023年第12期1829-1831,共3页Journal of Clinical Research

基　　金：2021年度湖南省卫生健康委科研立项项目一般指导课题(编号:202103102358)。

摘　　要：【目的】探讨肌注二巯基丙磺酸钠和口服二巯丁二酸胶囊治疗慢性砷中毒患者的临床疗效。【方法】回顾性分析2020年1月至2022年12月本院收治的206例慢性砷中毒患者的临床资料,按照治疗方法不同分为对照组(采用二巯丁二酸治疗)和观察组(采用肌注二巯基丙磺酸钠治疗),每组103例,两组患者连续治疗3个疗程。比较两组患者临床疗效及治疗前后头发中砷浓度、尿液中砷浓度。【结果】治疗后,两组患者头发中砷浓度、尿液中砷浓度显著低于治疗前,且观察组头发中砷浓度、尿液中砷浓度显著低于对照组,差异均有统计学意义(P<0.05)。观察组总有效率为68.93%(71/103),显著高于对照组的41.75%(43/103),差异有统计学意义(P<0.05)。【结论】慢性砷中毒治疗中,早诊断、早排除体内砷是重要措施;与二巯丁二酸相比,二巯基丙磺酸钠可显著提高慢性砷中毒患者的总体有效率。【Objective】To explore the clinical efficacy of intramuscular injection of sodium dimercaptosulfonate and oral administration of dimercaptosuccinic acid capsules in the treatment of patients with chronic arsenic poisoning.【Methods】A retrospective analysis was conducted on the clinical data of 206 patients with chronic arsenic poisoning admitted to our hospital from January 2020 to December 2022.According to different treatment methods,they were divided into a control group(treated with dimercaptosuccinic acid)and an observation group(treated with intramuscular injection of sodium dimercaptosulfonate),with 103 patients in each group.The two groups of patients were treated continuously for 3 courses of treatment.We compared the clinical efficacy and arsenic concentration in hair and urine between two groups of patients before and after treatment.【Results】After treatment,the arsenic concentration in the hair and urine of the two groups of patients was significantly lower than before treatment,and the arsenic concentration in the hair and urine of the observation group was significantly lower than that of the control group,with statistical significance(P<0.05).The total effective rate of the observation group was 68.93%(71/103),significantly higher than the control group's 41.75%(43/103),and the difference was statistically significant(P<0.05).【Conclusion】Early diagnosis and elimination of arsenic in the body are important measures in the treatment of chronic arsenic poisoning;Compared with dimercaptosuccinic acid,sodium dimercaptopropylsulfonate can significantly improve the overall effective rate of patients with chronic arsenic poisoning.

关 键 词：砷中毒/药物疗法 二巯琥珀酸/治疗应用 二巯丙磺钠 治疗结果 

分 类 号：R599.4[医药卫生—内科学]