慢性阻塞性肺疾病合并肺动脉高压患者血清白介素与肺动脉压力的相关性  

Correlation between serum interleukin and pulmonary artery pressure in patients with chronic obstructive pulmonary disease combined with pulmonary hypertension

作　　者：万引[1] 况卫丰[1] 陈轩[1] 曾招军 张爱妹[1] 李赞华[1] 熊国亮[1] WAN Yin;KUANG Weifeng;CHEN Xuan;ZENG Zhaojun;ZHANG Aimei;LI Zanhua;XIONG Guoliang(Department of Respiratory and Critical Care Medicine,Chest Hospital of Jiangxi Province,Nanchang 330006,China)

机构地区：[1]江西省胸科医院呼吸与危重症医学科,江西南昌330006

出　　处：《中国当代医药》2024年第2期26-29,共4页China Modern Medicine

基　　金：江西省卫生健康委科技计划项目(202211260)。

摘　　要：目的探讨慢性阻塞性肺疾病(COPD)合并肺动脉高压患者血清白介素(IL)与肺动脉压力的相关性。方法回顾性选取2022年1月至2023年2月江西省胸科医院呼吸与危重症医学科收治的60例COPD患者作为研究对象,根据是否合并肺动脉高压将其分为对照组(30例)与观察组(30例),对照组为COPD患者,观察组为COPD合并肺动脉高压患者。比较两组患者血清中IL-2、IL-10、IL-17表达水平,分析观察组患者血清中IL-2、IL-10、IL-17与肺动脉压力的相关性。结果观察组患者血清IL-2、IL-10水平均高于对照组,差异有统计学意义(P<0.05);两组患者血清IL-17水平比较,差异无统计学意义(P>0.05)。IL-2与肺动脉压力呈正相关(r=0.682,P=0.021),IL-10与肺动脉压力呈正相关(r=0.714,P=0.013),IL-17与肺动脉压力无明显相关性(r=0.171,P=0.152)。结论IL-2、IL-10与肺动脉高压形成有关,IL-17与肺动脉高压形成无相关性。Objective To investigate the correlation between serum interleukin(IL)and pulmonary artery pressure in serum of patients with chronic obstructive pulmonary disease(COPD)combined with pulmonary hypertension.Methods Sixty patients with COPD admitted to the Department of Respiratory and Critical Care Medicine,Chest Hospital of Jiangxi Province from January 2022 to February 2023 were retrospectively selected as research objects.They were divided into the control group(30 cases)and the observation group(30 cases)according to whether pulmonary hypertension was combined.The control group was COPD patients,and the observation group was COPD patients with pulmonary hypertension.The expression levels of IL-2,IL-10 and IL-17 in serum of the two groups were compared,and the correlation between IL-2,IL-10 and IL-17 in serum of the observation group and pulmonary artery pressure was analyzed.Results The levels of IL-2 and IL-10 in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in serum IL-17 between the two groups(P>0.05).IL-2 was positively correlated with pulmonary artery pressure(r=0.682,P=0.021),IL-10 was positively correlated with pulmonary artery pressure(r=0.714,P=0.013),and IL-17 was not significantly correlated with pulmonary artery pressure(r=0.171,P=0.152).Conclusion IL-2 and IL-10 are relate to the formation of pulmonary hypertension,while IL-17 is not relate to the formation of pulmonary hypertension.

关 键 词：慢性阻塞性肺疾病 肺动脉高压 白介素-2 白介素-10 白介素-17 

分 类 号：R563.9[医药卫生—呼吸系统]