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作 者:杨火梅 宋晓霞 张龙 YANG Huomei;SONG Xiaoxia;ZHANG Long(Department of Gynecology,Xinyu People's Hospital,Jiangxi Province,Xinyu338000,China)
机构地区:[1]江西省新余市人民医院妇科,江西新余338000
出 处:《中国当代医药》2024年第2期92-95,共4页China Modern Medicine
基 金:江西省卫生健康委科技计划项目(202311782)。
摘 要:目的观察雌激素补充联合右佐匹克隆治疗围绝经期睡眠障碍的临床价值。方法选取2020年9月至2022年9月新余市人民医院确诊的82例围绝经期睡眠障碍患者,根据患者自身选择分为对照组(39例)和观察组(43例),对照组采用雌二醇/雌二醇地屈孕酮片治疗,观察组在对照组的基础上加以右佐匹克隆治疗。观察两组治疗前后的匹兹堡睡眠质量指数量表(PSQI)和睡眠状况问卷自评量表(SRSS)的评分,比较患者的肝功能、血脂、空腹血糖水平,并记录两组的不良反应发生率。结果观察组患者治疗15 d后及治疗1、3个月后的PSQI和SRSS评分均低于对照组,差异有统计学意义(P<0.05)。两组患者治疗后的总胆红素(total bilirubin,TBil)、总胆固醇(TC)、空腹血糖比较,差异无统计学意义(P>0.05);两组患者治疗后的TBiL水平均高于本组治疗前,差异有统计学意义(P<0.05)。两组患者治疗期间的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论右佐匹克隆联合雌激素较单一雌激素治疗效果更显著,对围绝经期睡眠障碍患者疗效更显著且安全性高,值得临床联合用药治疗。Objective To observe the clinical value of estrogen supplementation combined with Dexzopiclone in the treatment of perimenopausal sleep disorders.Methods A total of 82 patients with perimenopausal sleep disorders diagnosed in Xinyu People's Hospital from September 2020 to September 2022 were selected and devided in the control group(39 cases)and the observation group(43 cases)according to the patients'own selection.The control group was treated with Estradiol/Estradiol and Dydrogesterone Tablets,and the observation group was treated with Dexzopicolone on the basis of the control group.Before and after treatment,the scores of Pittsburgh sleep quality index(PSQI)and self-rating scale of sleep(SRSS)were observed,the liver function,blood lipid and fasting blood glucose levels of the patients were compared,and the incidence of adverse reactions of the two groups was recorded.Results The PSQI and SRSS scores of the observation group were lower than those of the control group 15 days and 1 and 3 months after treatment,and the differences were statistically significant(P<0.05).There were no significant differences in total bilirubin(TBiL),total cholesterol(TC)and fasting blood glucose between the two groups after treatment(P>0.05).TBiL level after treatment in both groups were higher than those before the treatment,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups during treatment(P>0.05).Conclusion Dexzopiclone combined with estrogen is more effective than single estrogen treatment,and it is more effective and safe for patients with perimenopausal sleep disorders,which is worthy of clinical combined drug treatment.
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