Down-regulation of miR-486-5p expression inhibits the proliferation and invasion of human extravillous trophoblasts,and decreased peripheral plasma miR-486-5p level is associated with human early pregnancy loss  

作　　者：Yan Gu Ning Song Wen-Wen Gu Linghan Chen Xuan Zhang Jian Wang 

机构地区：[1]The Second Hospital of Tianjin Medical University,Tianjin 300221,China [2]NHC Key Lab of Reproduction Regulation(Shanghai Institute for Biomedical and Pharmaceutical Technologies),Shanghai 200032,China [3]Diagens Co.Ltd,Hangzhou 311121,China [4]Shanghai Key Laboratory of Reproductive Medicine,School of Medicine,Shanghai Jiao Tong University,Shanghai 200025,China [5]Hangzhou Yuhang Center for Disease Control and Prevention,Hangzhou 311113,China

出　　处：《Acta Biochimica et Biophysica Sinica》2023年第11期1847-1850,共4页生物化学与生物物理学报（英文版）

基　　金：supported by the grant from the Natural Science Foundation of Shanghai (No.23ZR1457000).

摘　　要：Recurrent miscarriage(RM)is defined as two or more consecutive pregnancy losses before 24 weeks of human pregnancy[1].The incidence of RM in pregnant women is 1%‒2%[2],and the RM causes in 50%of cases remain unknown[3].Fetal preservation has been widely applied for the threatened miscarriage of RM patients in early pregnancy;however,the failure of fetal preservation should be treated by uterine clearance surgery,which leads to inevitable endometrial damage and ovarian function decline.Thus,identifying a reliable index of fetal preservation is important for the clinical arrangement of early pregnancy loss(EPL),including RM.

关 键 词：pregnancy INVASION arrangement 

分 类 号：R714.1[医药卫生—妇产科学]