噬菌体治疗在骨科植入物感染中的研究进展  

Research progress of phage therapy in orthopedic implant-related infection

作　　者：祖力皮喀尔·买买提 李倬 徐驰[3] 付君[3] 郝立波[3] 刘亮[1] 陈继营[3] 柴伟[3] Maimaiti Zulipikaer;Li Zhuo;Xu Chi;Fu Jun;Hao Libo;Liu Liang;Chen Jiying;Chai Wei(Department of Orthopedics,Beijing Luhe Hospital,Capital Medical University,Beijing 101199,China;The Medical School of Nankai University,Tianjin 300074,China;Department of Orthopedics,the Fourth Medical Center,General Hospital,Chinese People's Liberation Army,Beijing 100048,China)

机构地区：[1]首都医科大学附属北京潞河医院骨中心,北京101199 [2]南开大学医学院,天津300074 [3]解放军总医院第四医学中心骨科医学部,北京100048

出　　处：《中华外科杂志》2024年第1期81-85,21,共6页Chinese Journal of Surgery

基　　金：国家重点研发计划(2020YFC2004900);北京市重大科技专项(Z221100003522014)。

摘　　要：随着植入材料在骨科疾病治疗中的应用逐渐普及,植入物相关并发症日益增多,其中以感染为最为严重。采取手术取出感染植入物并延长抗菌药物用药时间已被视为根除感染的有效策略。然而,由于抗菌药物耐药和生物膜的存在,感染难以控制或复发的情况屡见不鲜,对患者健康构成严重威胁。最新研究结果显示,噬菌体不仅可以直接杀灭致病菌,还具备降解生物膜的能力。联合使用噬菌体和抗菌药物,在临床试验中展现出了良好的治疗效果,有望成为处理植入物相关感染的有效解决方案。The widespread application of implantable materials has brought about a corresponding increase in implant-related complications,with implant-associated infections being the most critical.Biofilms,which often form on these implants,can significantly impede the effectiveness of traditional antibiotic therapies.Therefore,strategies such as surgical removal of infected implants and prolonged antibiotic treatment have been acknowledged as effective measures to eradicate these infections.However,the challenges of antibiotic resistance and biofilm persistence often result in recurrent or hard-to-control infections,posing severe health threats to patients.Recent studies suggest that phages,a type of virus,can directly eliminate pathogenic bacteria and degrade biofilms.Furthermore,clinical trials have demonstrated promising therapeutic results with the combined use of phages and antibiotics.Consequently,this innovative therapy holds significant potential as an effective solution for managing implant-associated infections.This paper rigorously investigates and evaluates the potential value of phage therapy in addressing orthopedic implant-associated infections,based on a comprehensive review of relevant scientific literature.

关 键 词：假体和植入物 假体相关感染 生物膜 细菌感染 噬菌体 抗菌药物 

分 类 号：R68[医药卫生—骨科学]