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作 者:莫荣纤 李洪珊 李殿玉 李向茸[1,2] 冯若飞[1,2] MO Rongqian;LI Hongshan;LI Dianyu;LI Xiangrong;FENG Ruofei(Key Laboratory of Biotechnology and Bioengineering of National Ethnic Affairs Commission,Biomedical Research Center,Northwest Minzu University,Lanzhou 730030,Gansu,China;College of Life Science and Engineering,Northwest Minzu University,Lanzhou 730030,Gansu,China)
机构地区:[1]西北民族大学生物医学研究中心,生物工程与技术国家民委重点实验室,甘肃兰州730030 [2]西北民族大学生命科学与工程学院,甘肃兰州730030
出 处:《微生物学报》2024年第1期42-60,共19页Acta Microbiologica Sinica
基 金:西北民族大学中央高校基本科研业务费资金(31920230163,31920230162);国家自然科学基金(32260037);科学技术部“高端外国专家引进计划”(G2022187005L)。
摘 要:维甲酸诱导基因I样受体家族(retinoid acid-inducible gene-I-like receptors,RLRs)信号通路作为众多抗感染免疫信号通路之一,在诱导促炎细胞因子、趋化因子和I型干扰素产生等方面发挥重要的调控作用。作为蛋白质翻译后修饰之一的泛素化(ubiquitination),是由泛素蛋白(ubiquitin)与目标蛋白上不同的氨基酸位点产生结合来调控蛋白的命运,如启动蛋白酶体途径降解蛋白或激活转运等功能。而RLRs信号通路分子的泛素化修饰既是调控多种效应因子的方式之一,也是病毒经此诱发动物重要疾病以及自身免疫病、慢性炎症的经典路径之一。本文主要综述RLRs信号通路中重要的效应器分子的典型结构特征、泛素化修饰类型和功能,探讨泛素化修饰调控RLRs信号通路关键分子的作用,为相关疾病的干预或治疗提供参考。Retinoid acid-inducible gene-I-like receptor(RLR)signaling pathways,the immune signaling pathways in response to infections,play a regulatory role in the production of pro-inflammatory cytokines,chemokines,and type I interferons.Ubiquitination as one of the post-translational modifications refers to the process of ubiquitin binding to different amino acid sites on the target proteins,which regulates the fates of proteins.For example,it initiates the proteasome pathway to degrade the target protein or activating the protein transport.The ubiquitination of RLR signaling pathways is a way of regulating multiple effectors and one of the classical pathways through which viruses induce major diseases in animals,autoimmune diseases,and chronic inflammation.This paper introduces the typical structural features and the ubiquitination types of key effectors in the RLR signaling pathways.Furthermore,it expounds the roles of ubiquitination in the regulation of key molecules in the RLR signaling pathways,aiming to provide a reference for the intervention or treatment of related diseases.
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