基于病证结合特点的绝经后骨质疏松症动物模型分析  

Analysis of the animal models of postmenopausal osteoporosis based on the combination of the disease and its syndromes

作　　者：陈明[1,2] 周帅琪 王尚全 展嘉文[1,2] 董永丽 齐保玉[1] 王达 尹煜辉[1,3] CHEN Ming;ZHOU Shuaiqi;WANG Shangquan;ZHAN Jiawen;DONG Yongli;QI Baoyu;WANG Da;YIN Yuhui(Wangjing Hospital of China Academy of Chinese Medical Sciences,Beijing 100102,China;Beijing Key Laboratory of Orthopedics of Traditional Chinese Medicine,Beijing 100102,China;Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]中国中医科学院望京医院,北京100102 [2]中医正骨技术北京市重点实验室,北京100102 [3]北京中医药大学,北京100029

出　　处：《吉林中医药》2024年第1期115-119,共5页Jilin Journal of Chinese Medicine

基　　金：中国中医科学院望京医院院级科研课题(WJYY2020-24);中国中医科学院望京医院自主选题专项课题(WJYY-ZZXT-2022-01)。

摘　　要：绝经后骨质疏松症(PMOP)病证结合动物模型在中医药研究中应用较多,但建立方法各式各样且缺乏统一的评价标准。文章从中医学和现代医学临床角度出发,就目前PMOP模型动物选择、构建方法和模型动物与临床吻合度进行对比,结合病证结合动物模型构建思路,从PMOP病证结合动物模型的构建和进一步完善评价方法进行归纳总结,以期为PMOP实验研究提供新思路。Animal models of postmenopausal osteoporosis(PMOP)combined with its syndromes have been widely used in TCM research,however,there exist various modelling methods and there is no unified evaluation criterion.From the clinical perspective of Chinese medicine and modern medicine,this paper makes a comparison in the selection of PMOP model animals,construction methods and the degree of conformity between model animals and clinical practice,and summarizes the construction and further improvement of the evaluation methods for PMOP animal models combined with the disease and its syndromes,in order to provide new ideas for the experimental research of PMOP.

关 键 词：绝经后骨质疏松症 病证结合 动物模型 实验研究 临床特征 

分 类 号：R274[医药卫生—中医骨伤科学]