基于GMR生物传感器的病原体检测研究进展  

Research Progress of Pathogens Detection Based on GMR Biosensors

作　　者：杨真 柳梦雨 孙逊 孙学成 王振宝 李丹青 徐军 Yang Zhen;Liu Mengyu;Sun Xun;Sun Xuecheng;Wang Zhenbao;Li Danqing;Xu Jun(a.School of Electronic and Information Engineering,Guangxi Normal University,Guilin 541004,China;School of Integrated Circuits,Guangxi Normal University,Guilin 541004,China;Key Laboratory of Integrated Circuits and Microsystems(Guangxi Normal University)of Education Department of Guangxi Zhuang Autonomous Region,Guangxi Normal University,Guilin 541004,China;Key Laboratory of Brain-Like Computing and Intelligent Chips,Guangxi Normal University,Guilin 541004,China;Institute of Guizhou Aerospace Measuring and Testing Technology,Guiyang 550009,China;Microelectronic Research&Development Center,School of Mechatronics Engineering and Automation,Shanghai University,Shanghai 200444,China;The Affiliated Hospital of Guizhou Medical University,Guiyang 550004,China)

机构地区：[1]广西师范大学电子与信息工程学院,广西桂林541004 [2]广西师范大学集成电路学院,广西桂林541004 [3]广西师范大学广西高校集成电路与微系统重点实验室,广西桂林541004 [4]广西师范大学类脑计算与智能芯片重点实验室,广西桂林541004 [5]贵州航天计量测试技术研究所,贵阳550009 [6]上海大学机电工程与自动化学院微电子研究与开发中心,上海200444 [7]贵州医科大学附属医院,贵阳550004

出　　处：《微纳电子技术》2024年第2期13-24,共12页Micronanoelectronic Technology

基　　金：广西自然科学基金面上项目(2023JJA170157);广西类脑计算与智能芯片重点实验室开放基金(BCIC-23-K8);广西科技基地和人才专项项目(2020AC19178);广西师范大学博士启动经费(DC2100001089);2023年广西师范大学研究生教育创新计划项目(JGY2023041,XYCSZ2023023);河南省留学人员科技择优计划资助项目;贵州省省级科技计划项目资助(黔科合支撑[2022]一般240)。

摘　　要：对当前病原体检测方法和磁性生物传感器的优势进行了简单阐述,分别介绍了巨磁阻(GMR)传感器在生物医学检测领域的应用优势、GMR效应的来源及常见的GMR传感器的结构类型,重点关注了GMR生物传感的基本原理,包括传感器在免疫分析领域的应用策略和传感器表面功能化的方法。总结了GMR生物传感器在病原体检测中的发展现状,重点阐述了GMR生物传感器在靶向标签、致病菌和病毒检测方面的实际应用。最后对当前GMR生物传感器在病原体检测领域面临的问题进行简要分析,对GMR生物传感器未来的应用前景进行了展望,为新一代可用于临床检测的GMR生物检测系统的开发奠定坚实的基础。The current methods of pathogens detection and the advantages of magnetic biosensors are briefly described.The application advantages of giant magneto-resistance(GMR)sensors in the field of biomolecule detection,the sources of the GMR effect and the structure types of common GMR sensors are introduced,respectively.The basic principles of GMR biosensing,including application strategies of sensors in the field of immunoassays and approaches of sensor surface functionalization are focused.The development status of GMR biosensors in the pathogens detection is summarized,focusing on the practical applications of GMR biosensors in targeted labelling,pathogenic bacteria and virus detections.Finally,the current problems faced by GMR biosensors in the field of pathogens detection are briefly analyzed,and the future application prospect of GMR biosensors is prospected,laying a good foundation for the development of a new generation of GMR biodetection systems for clinical detection.

关 键 词：巨磁阻(GMR)生物传感器 磁性生物传感器 生物医学检测 病原体检测 靶向标签 免疫分析 

分 类 号：TP212[自动化与计算机技术—检测技术与自动化装置] TH703[自动化与计算机技术—控制科学与工程]