盐酸曲唑酮治疗苯二氮卓类药物依赖性失眠症的效果研究  

Effect of trazodone hydrochloride on benzodiazepine-dependent insomnia

作　　者：刘洪秋[1] Liu Hongqiu(Tianjin Anning Hospital,Tianjin 300300,China)

机构地区：[1]天津市安宁医院,天津300300

出　　处：《首都食品与医药》2024年第1期67-70,共4页Capital Food Medicine

摘　　要：目的分析在为苯二氮卓类药物依赖性失眠症(Dependent insomnia,DI)患者实施治疗的过程中盐酸曲唑酮的应用效果。方法此研究实验对象的纳入时间为2021年3月-2023年3月,共包括在天津市安宁医院接受苯二氮卓类药物DI治疗的患者58例,以电脑随机分组法实现患者的分组,其中以常规方法实施治疗的29例患者作为对照组,在常规方法治疗基础上加用盐酸曲唑酮的29例患者作为观察组。结果观察组患者治疗效果与对照组患者相比,存在显著差异,P<0.05。两组患者治疗前药物依赖性、心理状态、睡眠质量均无显著差异,P>0.05;观察组患者治疗后药物依赖性较低,心理状态更为理想和稳定,且睡眠质量相对较高,与对照组患者相比,存在显著统计学差异,P<0.05。结论在为苯二氮卓类药物DI患者实施治疗的过程中,盐酸曲唑酮是一种相对较为理想的药物,有助于患者睡眠质量的提升、心理状态的改善以及药物依赖性的降低,值得予以临床分析以及推广应用。Objective To analyze the efficacy of trazodone hydrochloride in the treatment of patients with benzodiazepine-dependent insomnia(DI).Methods The subjects of this study were included from March 2021 to March 2023,including 58 patients who received benzodiazepine DI treatment in hospital.The patients were grouped by computer randomized method,and 29 patients who received conventional treatment were used as the control group.Observation group included 29 patients treated with trazodone hydrochloride on the basis of conventional treatment.Results There were significant differences in treatment efficacy between the observation group and the control group(P<0.05).There were no significant differences in drug dependence,mental state and sleep quality between the two groups before treatment(P>0.05).After treatment,patients in the observation group had lower drug dependence,more ideal and stable mental state,and relatively higher sleep quality,which showed significant statistical difference compared with patients in the control group(P<0.05).Conclusion Trazodone hydrochloride is a relatively ideal drug in the treatment of benzodiazepine DI patients,which is conducive to the improvement of sleep quality,mental state and drug dependence reduction of patients,and is worthy of clinical analysis and promotion.

关 键 词：盐酸曲唑酮 苯二氮卓类药物DI 心理状态 睡眠质量 

分 类 号：R971.3[医药卫生—药品]