败酱草中黄酮类化学成分影响大肠癌发生发展的作用机制研究进展  

Mechanism of Flavonoids in Patriniae Herba in Affecting Occurrence and Development of Colorectal Cancer

作　　者：张平平 贾茹 岑戎[1] 刘宏杰[1] 王炎[1] ZHNAG Pingping;JIA Ru;CEN Rong;LIU Hongjie;WANG Yan(Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院,上海201203

出　　处：《中国实验方剂学杂志》2024年第4期240-247,共8页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(82104619,82122075);上海市炎症性肿瘤转化病证生物学前沿研究基地项目(2021KJ03-12);促进市级医院临床技能与临床创新三年行动计划项目(SHDC2020CR4047);上海市浦东新区联合攻关项目(PW2020D-4);上海市卫健委卫生行业临床研究专项(20214Y0455)。

摘　　要：大肠癌是消化系统常见恶性肿瘤,居全球癌症发病谱第3位和死因谱第2位。近年来大肠癌发病率呈上升趋势,发病年龄呈现年轻化,癌症负担沉重,因此防治大肠癌发生发展及复发转移对降低大肠癌发病率和死亡率具有重要意义。败酱草具有清热解毒、消痈排脓的功效,对炎性肠病、消化道肿瘤、盆腔炎症、妇科肿瘤等多种疾病具有良好的疗效。临床常应用败酱草治疗大肠癌,但其作用机制尚不完全清楚。现代研究发现败酱草含有三萜类、皂苷、环烯醚萜类、黄酮类等多种化学成分,具有抗氧化、抗肿瘤、抗菌、抗病毒等多种药理作用,其中黄酮类化学成分是败酱草主要抗肿瘤成分,网络药理及谱效关系分析认为,槲皮素、木犀草素、芹菜素、异牡荆素、异红草苷在败酱草抑制大肠癌发生发展过程中起主要作用。体内外研究显示,败酱草中黄酮类化学成分可以从防止大肠癌癌前病变、抑制癌细胞生长增殖、阻滞癌细胞周期、促进癌细胞凋亡、逆转大肠癌耐药等多种途径发挥抗肿瘤作用。黄酮类化合物口服利用度低,肠道是黄酮类化合物在体内的主要代谢部位,其代谢途径与肠道微生物关系密切。该文对败酱草中主要黄酮类化学成分抗肿瘤机制及其对肠道微生物群影响相关研究做一综述,以期为深入研究败酱草抗大肠癌作用机制、转化临床应用提供研究思路。Colorectal cancer is a common malignant tumor in the digestive system,ranking third in incidence and second in the cause of death worldwide.In recent years,the incidence of colorectal cancer is on the rise,and the age of patients with colorectal cancer tends to be younger,with a heavy cancer burden.It is of great significance to prevent the occurrence,development,recurrence,and metastasis of colorectal cancer to reduce the incidence and mortality of colorectal cancer.Patriniae Herba has the effects of clearing heat,removing toxins,eliminating carbuncle,and discharging pus and shows good therapeutic efficacy on inflammatory bowel disease,digestive tract tumors,pelvic inflammation,gynecological tumor,and so on.Patriniae Herba is often used in the clinical treatment of colorectal cancer,but its mechanism of action is not clear.Modern studies have found that Patriniae Herba contains triterpenoids,saponins,iridoids,flavonoids,and other chemical components,with antioxidant,anti-tumor,anti-bacterial,and other pharmacological effects.The main anti-tumor components of Patriniae Herba are flavonoids.The analysis of network pharmacology and the spectrum-effect relationship has suggested that quercetin,luteolin,apigenin,isoorientin,and isovitexin play a major role in inhibiting the occurrence and development of colorectal cancer.In vivo and in vitro studies have shown that flavonoids in Patriniae Herba can play an anti-tumor role in various ways,such as preventing precancerous lesions of colorectal cancer,inhibiting the growth and proliferation of cancer cells,blocking cancer cell cycle,promoting cancer cell apoptosis,and reversing drug resistance of colorectal cancer.The oral availability of flavonoids is low.The gut is the main metabolic site of flavonoids in the body,its metabolic pathway is closely related to gut microbiota.This paper reviewed the anti-tumor mechanism of flavonoids and their influence on gut microbiota to provide a reference for further research on the mechanism of Patriniae Herba against colorectal canc

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分 类 号：R2-0[医药卫生—中医学] R22R242R2-031R285.5