基于NF-κB信号通路天然产物治疗特应性皮炎的研究进展  

Natural Products Treat Atopic Dermatitis via NF-κB Signaling Pathway:A Review

作　　者：李想 董玲玲 郭涛[2] 张理涛[2] LI Xiang;DONG Lingling;GUO Tao;ZHANG Litao(Graduate School,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital,Tianjin 300120,China)

机构地区：[1]天津中医药大学研究生院,天津301617 [2]天津市中医药研究院附属医院,天津300120

出　　处：《中国实验方剂学杂志》2024年第4期271-280,共10页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：天津市中医药重点领域科研项目(2022012)。

摘　　要：特应性皮炎是由内外多因素共同作用的慢性、复发性、炎症性、瘙痒性皮肤病,位居全球皮肤疾病负担首位。由于传统治疗和生物制剂的不良反应及高成本问题,天然产物的开发备受关注。核转录因子-κB(NF-κB)信号通路是抗炎和免疫调节的重要途径,故基于NF-κB信号通路系统,总结了黄酮类、生物碱、酚类、萜类、香豆素类、糖苷类、蒽醌类等天然产物的药理学作用与分子机制,以期为天然产物的开发提供一定指导。目前众多基础研究显示出天然产物具有较高的安全性和有效性,并通过口服或外用的给药方式及与磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt)、丝裂原活化蛋白激酶(MAPK)、核转录因子E2相关因子2(Nrf2)、高迁移率族蛋白B1(HMGB1)/晚期糖基化终产物受体(RAGE)、核苷酸结合寡聚结构域样受体蛋白3(NLRP3)等信号通路相互串扰的复杂药理学网络途径,发挥抗炎、抗过敏、抗氧化应激等作用,最终逆转特应性皮炎的病理改变。但值得注意的是,天然产物的临床应用转化尚相对不足,仍需更多更为严谨的临床试验加以验证。现有的基础试验及临床证据证明天然产物可能基于NF-κB信号通路发挥改善特应性皮炎的作用,这对评价天然活性物质的潜在机制提供依据,也为药物的开发提供了更多潜在候选者。Atopic dermatitis(AD)is a chronic,recurrent,inflammatory,and pruritus skin disease caused by multiple internal and external factors,ranking first in the global burden of skin diseases.Due to the adverse reactions and high costs of conventional treatments and biologics,the development of natural products has attracted much attention.The nuclear factor-κB(NF-κB)signaling pathway is a key pathway for inhibiting inflammation and modulating immunity.This paper summarizes the pharmacological effects and molecular mechanisms of natural products such as flavonoids,alkaloids,phenols,terpenoids,coumarins,glycosides,and anthraquinones via NF-κB signaling pathway,aiming to provide guidance for the development of natural products.Basic studies have shown that natural products have high safety and efficacy.Oral or topical administration of natural products can regulate the phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt),mitogen-activated protein kinase(MAPK),nuclear factor erythroid 2-related factor 2(Nrf2),high mobility group box 1 protein(HMGB1)/receptor for advanced glycation endproducts(RAGE),and nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)signaling pathways to exert anti-inflammatory,antiallergy,antioxidant activities,thus reversing the pathological changes of AD.However,it is worth noting that the clinical application of natural products is still insufficient,and more rigorous clinical trials are still needed to verify their effects.The basic experiments and clinical evidence prove that natural products may play a role in alleviating AD,which provide a basis for evaluating the functioning mechanism of natural active substances and enrich the candidates for the development of potential drugs.

关 键 词：天然产物 特应性皮炎 核转录因子-κB(NF-κB)信号通路 综述 

分 类 号：R2-0[医药卫生—中医学] R33[文化科学—情报学] G353.11R758.32