血常规相关参数在儿童支原体肺炎中的表达及临床价值  

Expression and clinical value of blood routine parameters in children with mycoplasma pneumonia

作　　者：恽琪 崔玥 张雯婷 顾猛[1] 赵静[2] YUN Qi;CUI Yue;ZHANG Wenting;GU Meng;ZHAO Jing(Department of Clinical Laboratory,Changzhou Children's Hospital Affiliated to Nantong University,Changzhou,213003,China;Department of Pediatric Laboratory,Changzhou Children's Hospital Affiliated to Nantong University)

机构地区：[1]南通大学附属常州儿童医院检验科,江苏常州213003 [2]南通大学附属常州儿童医院儿科实验室

出　　处：《临床血液学杂志》2023年第12期860-864,868,共6页Journal of Clinical Hematology

基　　金：常州市科技计划项目(No:CJ20210161)。

摘　　要：目的:分析支原体肺炎患儿血常规检查中血小板相关参数:血小板(PLT)、平均血小板体积(MPV)、血小板比容(PCT)和中性粒细胞(NEUT)、淋巴细胞(LYMPH)、单核细胞(MONO)及中性粒细胞/淋巴细胞比率(NLR)、血小板/淋巴细胞比率(PLR)的表达,探究其与支原体肺炎发生及患儿疾病转归的关联性和临床价值。方法:选取2020年6月—2022年8月收治的支原体肺炎患儿315例作为研究对象,根据患儿临床表现和机体免疫反应进程,结合肺炎支原体抗体水平,将患儿分为3组:感染早期组(110例)、感染中期组(105例)和感染后期组(100例)。同时期的健康体检者118例作为健康对照组。比较健康对照组和支原体肺炎感染各组的血常规相关参数表达水平;采用logistic回归分析法研究血常规相关参数对于支原体肺炎感染的风险和患儿疾病转归的预测价值;绘制受试者工作特征(ROC)曲线,分析评价血常规相关参数对支原体肺炎的诊断价值。结果:支原体肺炎各组与健康对照组之间PLT、MPV、PCT、LYMPH、MONO、NLR、PLR比较差异均有统计学意义(P<0.05),NEUT比较差异无统计学意义(P>0.05);低水平的LYMPH、高水平的MONO及高水平的PLR状态可以预测支原体肺炎感染的风险,PLT和MPV水平的波动可以较好地预测支原体肺炎患儿疾病转归;MONO最佳临界值为0.465时可辅助诊断支原体肺炎的感染,灵敏度为75.5%,特异度为73.7%。结论:血常规相关参数中MONO、NLR、PLR及LYMPH可作为支原体肺炎辅助诊断的潜在指标,血小板相关参数的监测可以预判机体免疫反应的进程和疾病转归。Objective:To analyze the expression of platelet-related parameters(PLT,MPV,PCT),neutrophils(NEUT),lymphocytes(LYMPH),monocytes(MONO),neutrophils/lymphocytes ratio(NLR)and platelet-lymphocyte ratio(PLR)in children with mycoplasma pneumonia,and explore the correlation and clinical value of mycoplasma pneumonia with the occurrence and prognosis of children.Methods:A total of 315 children with mycoplasma pneumonia admitted from June 2020 to August 2022 were selected as the research objects.According to the level of mycoplasma pneumonia antibody,the children were divided into three groups:early infection group(n=110),middle infection group(n=105)and late infection group(n=100).In the same period,118 healthy subjects were selected as healthy control group.The expression levels of blood routine parameters were compared between healthy control group and mycoplasma pneumonia infection group.Logistic regression analysis was used to study the predictive value of blood routine parameters for the risk of mycoplasma pneumonia infection and disease outcome in children.ROC curve was drawn to analyze and evaluate the diagnostic value of blood routine parameters for mycoplasma pneumonia.Results:There were significant differences in PLT,MPV,PCT,LYMPH,MONO,NLR and PLR between the two groups(P<0.05),and there was no significant difference in NEUT(P>0.05).The low level of LYMPH,high level of MONO and high level of PLR could predict the risk of mycoplasma pneumonia infection.The fluctuation of PLT and MPV levels could predict the disease outcome of children with mycoplasma pneumonia.The optimal cut-off value of MONO was 0.465.The sensitivity and specificity of MONO were 75.5%and 73.7%,respectively.Conclusion:MONO,NLR,PLR and LYMPH could be used as potential indicators for auxiliary diagnosis of mycoplasma pneumonia.The monitoring of platelet related parameters could predict the process of immune response and disease outcome.

关 键 词：血常规相关参数 支原体肺炎 血小板相关参数 免疫应答 疾病转归 

分 类 号：R563.1[医药卫生—呼吸系统]