鲤疱疹病毒二型(CyHV-Ⅱ)疫苗研究进展  

Research Progress of Cyprinid HerpesvirusⅡ(CyHV-Ⅱ)Vaccine

作　　者：吴琳娇 孙丽芳 朱春华[2] 张红 董盼盼[1] 陈磊清 吴允昆 WU Linjiao;SUN Lifang;ZHU Chunhua;ZHANG Hong;DONG Panpan;CHEN Leiqing;WU Yunkun(College of Life Sciences,Fujian Normal University,Fuzhou 350108,China;Institute of Animal Husbandry and Veterinary Medicine,Fujian Academy of Agricultural Sciences,Fuzhou 350013,China)

机构地区：[1]福建师范大学生命科学学院,福州350108 [2]福建省农业科学院畜牧兽医研究所,福州350013

出　　处：《中国农业科技导报》2024年第2期137-144,共8页Journal of Agricultural Science and Technology

摘　　要：鲤疱疹病毒Ⅱ型(Cyprinid herpesvirus Ⅱ,CyHV-Ⅱ)对任何发育时期的金鱼、鲫鱼及其杂交品种均具有感染能力,能够引起金鱼疱疹病(goldfish haematopoietic necrosis, GFHN),是一种传染性强且死亡率极高的疫病,给我国金鱼和鲫鱼养殖业造成巨大经济损失,鱼用疫苗的研发是预防和治疗该疫病最有效的办法。综述了CyHV-Ⅱ灭活疫苗、亚单位疫苗、核酸疫苗、活载体疫苗和纳米递送疫苗的研究进展,并对鱼用疫苗纳米材料的应用前景进行了探讨,以期为金鱼疱疹病害防治和鱼用疫苗研究提供新技术方法和新思路策略。Cyprinid herpesvirusⅡ(CyHV-Ⅱ)is the cause of(goldfish haematopoietic necrosis,GFHN),which can infect goldfish,Crucian carp and their hybrid at any developmental stage.It is a highly contagious disease with high mortality rate,which has caused huge economic losses to goldfish and Crucian carp aquaculture in China.The research and development of fish vaccine is the most effective way to prevent and treat the disease.The research and development progress of inactivated CyHV-Ⅱvaccine,subunit vaccine,nucleic acid vaccine,live vector vaccine and Nano-delivered vaccines were reviewed in this paper.Furthermore,the application prospect of fish vaccine nano materials was discussed,which would provide new technical methods and new ideas for the prevention and treatment of goldfish herpes disease and fish vaccine research.

关 键 词：鲤疱疹病毒二型(CyHV-Ⅱ) 免疫途径 纳米材料 疫苗类型 

分 类 号：S943[农业科学—水产养殖]