南京市鼓楼社区老年人群高脂血症与内皮细胞微粒的相关性  

Correlation between hyperlipidemia and endothelial microparticles in elderly patients from Gulou Community in Nanjing

作　　者：杨茜岚 汪金玉 刘舒予 占伊扬 刘菁 贾坚 YANG Xilan;WANG Jinyu;LIU Shuyu;ZHAN Yiyang;LIU Jing;JIA Jian(Department of General Practice,the Fourth Affiliated Hospital of Nanjing Medical University,Nanjing 210031,Jiangsu,China;Department of Cardiology,General Hospital of the Yangtze River Shipping,Wuhan 430000 Hubei,China;Department of General Practice,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210036,Jiangsu,China)

机构地区：[1]南京医科大学第四附属医院全科医学科,江苏南京210031 [2]长江航运总医院心内科,湖北武汉430000 [3]南京医科大学第一附属医院全科医学科,江苏南京210036

出　　处：《检验医学》2023年第12期1167-1172,共6页Laboratory Medicine

基　　金：江苏省“六大人才高峰”高层次人才项目(WSN-024);江苏省基层卫生发展与全科医学教育研究中心开放课题(2019B03);江苏省老年健康科研项目(LK2021009)。

摘　　要：目的探讨南京市鼓楼社区老年人群高脂血症与内皮细胞微粒(EMP)的关系。方法选取2020年7月—2021年6月南京医科大学第四附属医院首次确诊,且来源于南京市鼓楼社区的老年高脂血症患者100例(高脂血症组),以老年健康体检者100名为正常对照组。收集所有对象的一般资料,并检测血常规[白细胞(WBC)计数、红细胞(RBC)计数、血小板(PLT)计数、血红蛋白(Hb)]、生化项目[三酰甘油(TG)、总胆固醇(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、血尿素氮(BUN)、血清肌酐(SCr)、尿酸(UA)、空腹血糖(FBG)、高敏C反应蛋白(hs-CRP)]、炎症因子[白细胞介素(IL)-1β、肿瘤坏死因子α(TNF-α)]和EMP。采用二元Logistic回归分析评估老年人群发生高脂血症的危险因素。结果与正常对照组比较,高脂血症组TC、TG、LDL-C、ALT、AST、hs-CRP、IL-1β、TNF-α和EMP水平均显著升高(P<0.01),HDL-C水平显著降低(P<0.001)。2个组之间BUN、SCr、UA、FBG差异无统计学意义(P>0.05)。多因素Logistic回归分析结果显示,AST、hs-CRP、TNF-α、收缩压、EMP是老年人群发生高脂血症的独立危险因素[比值比(OR)值分别为1.089、1.528、1.048、1.065、1.946,95%可信区间(CI)分别为1.031~1.150、1.197~1.951、1.024~1.072、1.026~1.106、1.166~3.248,P<0.05]。结论EMP或可作为老年高脂血症患者内皮损伤的生物标志物。Objective To investigate the correlation between endothelial microparticles(EMP)and hyperlipidemia in elderly patients from Gulou Community in Nanjing.Methods Totally,100 elderly patients first diagnosed with hyperlipidemia at the Fourth Affiliated Hospital of Nanjing Medical University from Gulou Community in Nanjing from July 2020 to June 2021 were enrolled as hyperlipidemia group,while 100 healthy elderly subjects were enrolled as control group.The general data,blood routine test results[white blood cell(WBC)count,red blood cell(RBC)count,platelet(PLT)count,hemoglobin(Hb)],biochemical item determination results[triglyceride(TG),total cholesterol(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),alanine aminotransferase(ALT),aspartate aminotransferase(AST),blood urea nitrogen(BUN),serum creatinine(SCr),uric acid(UA),fasting blood glucose(FBG),high-sensitivity C-reactive protein(hs-CRP)],inflammatory factor determination results[interleukin(IL)-1β,tumor necrosis factor-alpha(TNF-α)]and EMP were collected.The independent risk factors of hyperlipidemia were analyzed by binary Logistic regression.Results Compared with control group,the levels of TC,TG,LDL-C,ALT,AST,hs-CRP,IL-1β,TNF-αand EMP in hyperlipidemia group were increased(P<0.01),and the levels of HDL-C were decreased(P<0.001).There was no statistical significance in BUN,SCr,UA and FBG between the 2 groups(P>0.05).Multivariate Logistic regression analysis showed that AST,hs-CRP,TNF-α,systolic blood pressure and EMP were independent risk factors for hyperlipidemic in elderly population[odds ratios(OR)were 1.089,1.528,1.048,1.065 and 1.946,95% confidence intervals(CI)were 1.031-1.150,1.197-1.951,1.024-1.072,1.026-1.106 and 1.166-3.248,P<0.05].Conclusions EMP may be used as a biomarker of endothelial injury in elderly patients with hyperlipidemia.

关 键 词：内皮细胞微粒 血管内皮损伤 高脂血症 炎症 

分 类 号：R446.1[医药卫生—诊断学]