2020年洛阳市偃师区健康人群A群和C群脑膜炎奈瑟菌抗体水平调查  

Antibody levels against group A and C Neisseria meningitis among healthy population in Yanshi district, Luoyang city in 2020

作　　者：张露露 仝志琴[1] 杨闪[1] ZHANG Lulu;TONG Zhiqin;YANG Shan(Luoyang Center for Disease Control and Prevention,Luoyang 471000,Henan,China)

机构地区：[1]洛阳市疾病预防控制中心,河南洛阳471000

出　　处：《现代疾病预防控制》2024年第1期59-62,共4页MODERN DISEASE CONTROL AND PREVENTION

摘　　要：目的 了解河南省洛阳市偃师区健康人群A群和C群脑膜炎奈瑟菌(Nm)抗体水平,为流行性脑脊髓膜炎的预防控制提供科学依据。方法 采用分层随机抽样的方法,于2020年在偃师区选取0~79岁健康人群进行问卷调查和血清标本采集。采用酶联免疫吸附试验检测血清中A群和C群Nm Ig G抗体,分析其抗体阳性率和中位数浓度(MC)。结果 全部628名调查对象的A群、C群Nm抗体总阳性率分别为51.59%、40.76%(χ^(2)=14.81,P<0.05),MC分别为2.13、1.49μg/m L(H=33.28,P<0.05)。不同年龄组A群Nm抗体阳性率为13.85%~71.43%(χ^(2)=109.40,P<0.05),1~<3岁组最低,20~<40岁组最高;C群Nm抗体阳性率为13.85%~70.48%(χ^(2)=90.98,P<0.05),0~<1岁组最低,40~<60岁组最高。其中<15岁有明确免疫史人群中,A群Nm抗体阳性率,随着接种剂次从1剂次到4剂次,逐渐升高;C群Nm抗体阳性率,随着接种剂次从0剂次到2剂次,逐渐增高;末次免疫后1~<2年,A群和C群的Nm抗体水平均降到最低(P均<0.05)。结论 洛阳市偃师区健康人群A群和C群Nm抗体处于较低水平,建议加强流行性脑脊髓膜炎的监测,优化流脑疫苗免疫策略。Objective To explore antibody levels against group A and C Neisseria meningitis(Nm) among a healthy population in Yanshi district, Luoyang city, and provide scientific evidence for the prevention and control of meningococcal meningitis. Methods Serum samples were collected from healthy individuals selected by a stratified random sampling technique in Yanshi district,Luoyang city in 2020. At the same time, a questionnaire-based survey was conducted among the selected individuals. The serum samples were tested by an enzyme-linked immunosorbent assay to detect serum Ig G antibodies against group A and C Nm to determine positivity rates and median concentrations(MC). Results Among the 628 individuals surveyed, the overall positive rates of antibodies against serogroup A and C Nm were 51.59% and 40.76%, respectively( χ~2=14.81, P<0.05), and the MC of the antibodies were 2.13 μg/mL and 1.49 μg/m L(H= 33.28, P<0.05), respectively. By age group, positive rates of antibodies against group A ranged from 13.85% to 71.43%( χ~2=109.40, P<0.05) with the lowest in the 1-<3 years old group and the highest in the20-<40 years old group, and they ranged from 13.85% to 70.48% against group C( χ~2= 90.98,P<0.05) with the lowest in the0-<1 years old group and the highest in the 40-<60 years old group. Among the surveyed individuals aged <15 years and having the clear vaccination history, the positive rates of antibodies against group A gradually increased with the doses of vaccinations from 1 to 4;they increased from 0 to 2 doses against serogroup C. The antibody levels against group A and C Nm both reached to a minimum 1-<2 years after last vaccination(all P<0.05). Conclusions Antibody levels against group A and C Nm among the healthy population in Yanshi district, Luoyang city, were relatively low. It is suggested to strengthen surveillance of meningococcal meningitis and optimize the immunization strategy of meningococcal vaccine.

关 键 词：流行性脑脊髓膜炎 脑膜炎奈瑟菌 健康人群 抗体水平 

分 类 号：R186[医药卫生—流行病学]