铁死亡在非酒精性脂肪性肝病发病中作用的研究进展  

Research progress on the role of ferroptosisin the pathogenesis of non-alcoholic fatty liver disease

作　　者：肖艳新[1] 刘岩[2] 许岭翎 周亚茹[2] XIAO Yanxin;LIU Yan;XU Lingling;ZHOU Yaru(Department of Endocrinology,Baoding NO.1 Central Hospital,Baoding 071000;Department of Endocrinology,the Third Hospital of Hebei Medical University,Shijiazhuang 050051;Key Laboratory of Endocrinology of National Health Commission,Department of Endocrinology,Peking Union Medical College Hospital,CAMS&PUMC,Beijing 100730,China)

机构地区：[1]保定市第一中心医院内分泌科,河北保定071000 [2]河北医科大学附属第三医院内分泌科,河北石家庄050051 [3]中国医学科学院,北京协和医学院,北京协和医院内分泌科,国家卫生健康委员会内分泌重点实验室,北京100730

出　　处：《基础医学与临床》2024年第2期260-264,共5页Basic and Clinical Medicine

基　　金：河北省自然科学基金(H2021206073)。

摘　　要：铁死亡是近年提出的一种新型细胞死亡方式,其主要特征为铁过载及脂质过氧化。铁死亡参与非酒精性脂肪性肝病的发生发展。铁过载可通过芬顿反应产生大量活性氧,在脂氧合酶的作用下,肝细胞膜上的不饱和脂肪酸发生脂质过氧化,从而诱导肝细胞死亡,导致非酒精性脂肪性肝病/非酒精性脂肪性肝炎的发生。阻断铁死亡可能成为保护肝细胞的治疗策略之一。Ferroptosis is a new type of cell death proposed in recent years,and its main characteristics are iron overload and lipid peroxidation.Ferroptosis is involved in the occurrence and development of non-alcoholic fatty liver disease(NAFLD).Iron overload can generate a large amount of reactive oxygen species through the Fenton reaction.Under the action of lipoxygenase,the unsaturated fatty acids on the liver cell membrane undergo lipid peroxidation,which induces liver cell death and leads to the occurrence of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis.Blocking ferroptosis may provide one of the therapeutic strategies to protect liver cells.

关 键 词：铁死亡 非酒精性脂肪性肝病 脂质过氧化 铁过载 

分 类 号：R589.2[医药卫生—内分泌]